Frozen with fear: Conditioned suppression in a virtual reality model of human anxiety
Frozen with fear: Conditioned suppression in a virtual reality model of human anxiety
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DOI：
10.1016/j.beproc.2015.06.011
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发表时间：
2015-09-01
影响因子：
1.3
通讯作者：
Dymond, Simon
中科院分区：
文献类型：
--
作者：
Allcoat, Devon;Greville, W. James;Dymond, Simon
在条件性抑制任务中，通过呈现相对于安全性提示的令人厌恶的条件性威胁提示来降低食欲行为，从而引起行为的冻结样地形。巴甫洛夫威胁线索对操作性行为的条件性抑制是一种已建立的量化焦虑症反应障碍的实验室模型。然而，很少有人知道不同的反应地形指示条件性抑制在人类引起的。在这里，我们改进了一种新的虚拟现实（VR）模式，在这种模式中，当参与者进行射击和破坏盒子寻找隐藏的黄金的操作性反应时，会出现不可预测的持续时间的威胁线索。VR范式检测到显着抑制的反应地形（射击，命中和休息）的巴甫洛夫威胁线索相对于安全线索和新的线索介绍。本研究结果对焦虑症中食欲和厌恶冲突的翻译研究的意义进行了讨论。(C)2015爱思唯尔B.V.保留所有权利。
Freezing-like topographies of behavior are elicited in conditioned suppression tasks whereby appetitive behavior is reduced by presentations of an aversively conditioned threat cue relative to a safety cue. Conditioned suppression of operant behavior by a Pavlovian threat cue is an established laboratory model of quantifying the response impairment seen in anxiety disorders. Little is known however about how different response topographies indicative of conditioned suppression are elicited in humans. Here, we refined a novel virtual reality (VR) paradigm in which presentations of a threat cue of unpredictable duration occurred while participants performed an operant response of shooting and destroying boxes searching for hidden gold. The VR paradigm detected significant suppression of response topographies (shots, hits and breaks) for a Pavlovian threat cue relative to a safety cue and novel cue presentations. Implications of the present findings for translational research on appetitive and aversive conflict in anxiety disorders are discussed. (C) 2015 Elsevier B.V. All rights reserved.