Inflammation and atrial fibrillation: A comprehensive review.
Inflammation and atrial fibrillation: A comprehensive review.
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DOI：
10.1002/joa3.12077
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发表时间：
2018-08
影响因子：
2
通讯作者：
Liu T
中科院分区：
文献类型：
--
作者：
Korantzopoulos P;Letsas KP;Tse G;Fragakis N;Goudis CA;Liu T
心房颤动（AF）有不同的潜在底物。心房重构涉及电生理和结构异常，促进AF的发展和永久化。实验和临床数据表明，炎症与心房重构的病理生理学有关。心房重构和炎症之间的机制联系是复杂的，而不同的基础疾病和条件可能会影响这些途径。炎症标志物也与房颤的发生、复发、永久化、总房颤负荷以及血栓栓塞并发症相关。在这种情况下，开发特定的抗炎干预措施似乎具有挑战性和复杂性。几种具有多效性的药物，包括抗炎药，已在实验和临床环境中进行了测试，结果各不相同。这篇更新的综述提供了关于炎症在AF中作用的所有可用数据的简要概述，包括炎症标志物的预测作用。此外，目前的知识和抗炎策略的未来方向进行了批判性的讨论。
Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti‐inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti‐inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti‐inflammatory strategies are critically discussed.