Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice
Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice
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DOI：
10.3389/neuro.08.025.2009
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发表时间：
2009-01-01
影响因子：
3
通讯作者：
Champagne, Frances A.
中科院分区：
文献类型：
--
作者：
Curley, James P.;Davidson, Stephanie;Champagne, Frances A.
在各个物种中，有证据表明早期社会环境的质量可以对神经生物学和行为产生深远的影响。在本研究中，我们探讨了在出生后的Balb/c小鼠的后代（F1）和孙子（F2）焦虑样和母性行为的公共饲养条件（三个母鼠，每笼三窝）的影响。女性饲养幼崽在公共巢表现出产后产妇护理和公共饲养水平的提高，发现取消断奶体重的性别差异。在成年期，当被置于一个新的环境中时，观察到共同饲养的后代表现出减少的焦虑样行为。当饲养自己的后代在标准条件下，共同饲养的女性表现出更高水平的动机，检索幼崽，建立更高质量的巢，并表现出更高水平的产后护理相比，标准饲养的女性。当暴露于一个入侵者男性，共同饲养的女性更从属，少侵略性。观察到共同饲养雌性的F2后代在PND 1时焦虑样行为减少，窝仔数增加，哺乳频率增加。神经肽受体水平的分析表明，公共饲养环境可能会产生持续的影响，通过修改催产素和加压素（V1 a）受体密度的行为。虽然Balb-C小鼠通常被认为是“社会无能”和高焦虑样行为，我们的研究结果表明，通过丰富的出生后环境，这些行为和神经内分泌缺陷可能会减弱内和跨代。
Across species there is evidence that the quality of the early social environment can have a profound impact on neurobiology and behavior. In the present study we explore the effect of communal rearing conditions (three dams with three litters per cage) during the postnatal period on offspring (F1) and grand-offspring (F2) anxiety-like and maternal behavior in Balb/c mice. Females rearing pups in communal nests exhibited increased levels of postpartum maternal care and communal rearing was found to abolish sex-differences in weaning weights. In adulthood, communally reared offspring were observed to display reduced anxiety-like behavior when placed in a novel environment. When rearing their own offspring under standard conditions, communally reared females demonstrated higher levels of motivation to retrieve pups, built higher quality nests, and exhibited higher levels of postpartum care compared to standard reared females. When exposed to an intruder male, communally reared females were more subordinate and less aggressive. F2 offspring of communally reared females were observed to engage in reduced anxiety-like behavior, have larger litter sizes and an increased frequency of nursing on PND 1. Analysis of neuropeptide receptor levels suggest that a communal rearing environment may exert sustained effects on behavior through modification of oxytocin and vasopressin (V1a) receptor densities. Though Balb-C mice are often considered "socially-incompetent" and high in anxiety-like behavior, our findings suggest that through enrichment of the postnatal environment, these behavioral and neuroendocrine deficits may be attenuated both within and across generations.