Fever-inducing sympathetic neural pathways
Fever-inducing sympathetic neural pathways
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DOI：
10.1016/j.jtherbio.2004.08.001
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发表时间：
2004-10-01
影响因子：
2.7
通讯作者：
Nakamura, K
中科院分区：
文献类型：
--
作者：
Nakamura, K
1.发烧是众所周知的疾病的标志，由神经系统的活动引起。2.一般认为，前列腺素E-2在视前区的作用触发了交感神经系统的刺激，从而导致发热的产生。3.最近的研究表明，延髓中缝吻侧区域是POA向交感输出神经元传递热原信号的关键区域。4.在这里，我综述了这些中缝区域在发热反应中的功能作用，并讨论了POA向中缝区域的热源传递。(C)2004爱思唯尔有限公司。保留所有权利。
1. Fever is the widely known hallmark of disease and induced by the action of the nervous system. 2. It is generally accepted that the action of prostaglandin E-2 in the preoptic area (POA) triggers the stimulation of the sympathetic nervous system, and this results in the production of fever. 3. Recent findings have demonstrated that the rostral medullary raphe regions are essential for the pyrogenic signal transmission from the POA to sympathetic output neurons. 4. Here, I review the functional role of these raphe regions in febrile responses and also discuss the pyrogenic transmission from the POA to the raphe regions. (C) 2004 Elsevier Ltd. All rights reserved.