Interaction between radiation and drug damage in mammalian cells. III. The effect of adriamycin and actinomycin-D on the repair of potentially lethal radiation damage.
Interaction between radiation and drug damage in mammalian cells. III. The effect of adriamycin and actinomycin-D on the repair of potentially lethal radiation damage.
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哺乳动物细胞中辐射和药物损伤之间的相互作用。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
James A. Belli
中科院分区：
文献类型：
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作者：
Anatoly Dritschilo;Anthony J. Piro;James A. Belli
本文研究了放线菌素- d （AMD）和阿霉素（ADRM）对高原期中国仓鼠细胞（V79）辐射损伤修复的影响。在无毒水平的AMD和最低毒性水平的ADRM的存在下，观察到潜在致命损伤修复（PLDR）的抑制。只要药物存在，AMD对PLDR的抑制作用就会持续存在。AMD切除后，可能致命的损伤会迅速修复，这表明AMD对PLDR的抑制并不伴随着将损伤固定到不可修复状态。另一方面，暴露于ADRM的辐照细胞经过最初的延迟后，最终在药物存在下修复了潜在的致命损伤。AMD抑制亚致死辐射损伤的修复，而ADRM没有。
We have studied the effects of actinomycin-D (AMD) and Adriamycin (ADRM) on the repair of radiation damage in Chinese hamster cells (V79) in plateau phase growth. Suppression of potentially lethal damage repair (PLDR) was observed in the presence of non-toxic levels of AMD and minimally toxic levels of ADRM. The suppression of PLDR by AMD persisted as long as the drug was present. Removal of AMD was followed by prompt repair of potentially lethal injury suggesting that suppression of PLDR by AMD was not accompanied by fixation of injury to a non-repairable state. On the other hand, irradiated cells exposed to ADRM eventually repair potentially lethal injury in the presence of drug after an initial delay. AMD, but not ADRM, inhibited repair of sublethal radiation damage.