Muscular effects of orexin A on the mouse duodenum: mechanical and electrophysiological studies
Muscular effects of orexin A on the mouse duodenum: mechanical and electrophysiological studies
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食欲素 A 对小鼠十二指肠的肌肉影响：机械和电生理学研究
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
M. C. Baccari
中科院分区：
文献类型：
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作者：
R. Squecco;R. Garella;Giorgia Luciani;F. Francini;M. C. Baccari
非技术摘要 已经报道了神经介导的食欲素 A 对胃肠运动的影响，无论是集中注射还是应用于分离的肠道制剂。然而，已经发现胃肠道平滑肌水平存在食欲素受体。基于这些理由，在本研究中，我们评估了食欲素 A 是否也在小鼠十二指肠平滑肌中发挥直接的肌肉作用，试图解释所涉及的可能的作用机制。机械和电生理学研究的实验结果表明，食欲素 A 在分离的制剂中引起直接收缩反应，并引起平滑肌细胞离子电流的变化。因此，食欲素 A 除了对胃肠运动产生中性介导的影响外，还对小鼠十二指肠产生直接的肌肉作用。从生理学的角度来看，后一种机制可能以协同方式发挥作用，以增强神经元信号。
Non‐Technical Summary Nerve‐mediated influences on gastrointestinal motility in response to orexin A, either centrally injected or applied to isolated gut preparations, have been reported. However, the presence of orexin receptors at the gastrointestinal smooth muscle level has been found. On these grounds, in the present study we evaluated whether orexin A also exerts direct muscular effects in the duodenal smooth muscle of the mouse in an attempt to explain the possible mechanism of action involved. The experimental results from mechanical and electrophysiological studies indicate that orexin A causes direct contractile responses in the isolated preparations and evokes changes in the ionic currents of the smooth muscle cells. Thus, orexin A, in addition to its neutrally mediated influences on gastrointestinal motility, exerts direct muscular effects on the mouse duodenum. This latter mechanism, from a physiological point of view, may act in a synergic manner to reinforce the neuronal signals.
DOI：
10.1152/ajpgi.00264.2001
发表时间：
2002-08-01
影响因子：
4.5
作者：
Krowicki, ZK;Burmeister, MA;Hornby, PJ
通讯作者：
Hornby, PJ
影响因子：
5.8
作者：
Ehrström, M;Gustafsson, T;Näslund, E
通讯作者：
Näslund, E