CRYPTORCHIDISM, AN EPIDEMIOLOGIC-STUDY WITH EMPHASIS ON THE RELATIONSHIP TO CENTRAL NERVOUS-SYSTEM DYSFUNCTION
CRYPTORCHIDISM, AN EPIDEMIOLOGIC-STUDY WITH EMPHASIS ON THE RELATIONSHIP TO CENTRAL NERVOUS-SYSTEM DYSFUNCTION
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DOI：
10.1002/tera.1420370403
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发表时间：
1988-04-01
期刊：
影响因子：
--
通讯作者：
DEPUE, RH
中科院分区：
文献类型：
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作者：
DEPUE, RH
本病例对照研究探讨隐睾与中枢神经系统功能障碍的关系。脑性瘫痪（RR = 34）、低智商（RR = 2.7）和Bayley测试测量的低运动功能（RR = 3.6）的比值比升高。低智商和脑瘫是隐睾的独立危险因素。臀位分娩（RR = 2.6）、妊娠< 34周（RR = 2.0）和双胞胎（RR = 4.1）也是独立风险。其他危险因素是母亲使用雌激素（RR = 3.3）和母亲克托莱指数< 24（RR = 1.6）。所有这些风险都具有统计学意义。这些因素表明隐睾症可能是由性类固醇直接作用于睾丸或中枢神经系统损伤引起的，中枢神经系统损伤反过来又引起垂体促性腺激素抑制。双胞胎和小婴儿中隐睾发生率的增加表明，胎儿发育迟缓可能是睾丸发育不良的另一种机制。
This case-control study examines the relation of cryptorchidism to central nervous system dysfunction. Elevated odd ratios were found for cerebral palsy (RR = 34), low IQ (RR = 2.7), and low motor function measured by the Bayley test (RR = 3.6). Low IQ and cerebral palsy were independent risk factors for cryptorchidism. Breech labor (RR = 2.6), a gestation < 34 weeks (RR = 2.0), and being a twin (RR = 4.1) were also independent risks. Other risk factors were estrogen use by the mother (RR = 3.3) and a maternal Quetelet index < 24 (RR = 1.6). All of these risks were statistically significant. These factors suggest that cryptorchidism may be caused either by sex steroid action directly on the testes or by CNS damage, which in turn causes suppression of pituitary gonadotropins. The increased occurrence of cyptorchidism in twins and small babies indicates that retarded general fetal development can be another mechanism for maldescent of the testes.