THE GENE CODING FOR THE MAJOR BIRCH POLLEN ALLERGEN BETVL, IS HIGHLY HOMOLOGOUS TO A PEA DISEASE RESISTANCE RESPONSE GENE
THE GENE CODING FOR THE MAJOR BIRCH POLLEN ALLERGEN BETVL, IS HIGHLY HOMOLOGOUS TO A PEA DISEASE RESISTANCE RESPONSE GENE
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DOI：
10.1002/j.1460-2075.1989.tb03597.x
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发表时间：
1989-07-01
期刊：
影响因子：
11.4
通讯作者：
BREITENBACH, M
中科院分区：
文献类型：
--
作者：
BREITENEDER, H;PETTENBURGER, K;BREITENBACH, M
白色桦树（Betula verrucosa）的花粉是中欧和北方欧洲、北美和苏联的I型过敏反应（过敏性鼻结膜炎、过敏性支气管哮喘）的主要原因之一。I型过敏是这些国家公共卫生的主要威胁，因为10-15%的人口患有这些疾病。BetvI是一种Mr为17 kd的过敏原蛋白，是白色桦树花粉的组成部分，并负责超过95%的桦树花粉过敏患者的IgE结合。在这里，我们报告的完整的核苷酸序列和推导的氨基酸序列的cDNA克隆编码的主要花粉过敏原（BetvI）的白色桦树。它与榛、桤木和角木（近亲）过敏原的N-末端肽序列相似，但与任何其他已知过敏原没有显著的序列同源性。然而，它与豌豆抗病反应基因显示55%的序列同一性，表明BetvI可能参与花粉的病原体抗性。
Pollen of the white birch (Betula verrucosa) is one of the main causes of Type I allergic reactions (allergic rhinoconjuctivitis, allergic bronchial asthma) in Middle and Northern Europe, North America and the USSR. Type I allergies are a major threat to public health in these countries, since 10-15% of the population suffer from these diseases. BetvI, an allergenic protein with an Mr of 17 kd is a constituent of the pollen of white birch and is responsible for IgE binding in more than 95% of birch pollen allergic patients. Here, we report the complete nucleotide sequence and deduced amino acid sequence of a cDNA clone coding for the major pollen allergen (BetvI) of white birch. It is similar to the N-terminal peptide sequences of the allergens of hazel, alder and hornbeam (close relatives) but it has no significant sequence homology to any other known allergens. However, it shows 55% sequence identity with a pea disease resistance response gene, indicating that BetvI may be involved in pathogen resistance of pollen.