Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men.
Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men.
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DOI：
10.1002/pros.20943
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发表时间：
2009-06-15
期刊：
影响因子：
2.8
通讯作者：
Petros, John A.
中科院分区：
文献类型：
--
作者：
Ray, Anna M.;Zuhlke, Kimberly A.;Levin, Albert M.;Douglas, Julie A.;Cooney, Kathleen A.;Petros, John A.
以前的研究已经发现线粒体DNA（mtDNA）突变与几种癌症类型之间的关联。最近，我们发现线粒体DNA基因细胞色素c氧化酶亚基1（COI）的突变与高加索男性前列腺癌（PCa）相关。在这里，我们研究COI突变和PCa在非洲裔美国人之间的关联。整个COI基因直接测序132例PCa病例和135例对照来自弗林特男性健康研究，一个以社区为基础的样本的非洲裔美国人与非PCa。评估所有变体与PCa之间的关联。我们鉴定了102个COI单核苷酸多态性（SNP），包括15个错义变体。总的来说，一个或多个COI错义变异的存在与PCa无显著相关性。在个体上，两个SNP（T6221C和T7389C）与前列腺癌显著相关（P < 0.05），并且彼此之间存在强连锁不平衡（r2 > 0.6）。在两个显著相关的SNP中，一个是同义替换，另一个是非洲特异性线粒体单倍群（L）的一部分。将需要更多的研究来确定这些协会在非洲人群的临床意义。
Previous studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 (COI) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we examine the association between COI mutations and PCa in African American men. The entire COI gene was directly sequenced in 132 PCa cases and 135 controls from the Flint Men’s Health Study, a community-based sample of African American men with and without PCa. Associations between all variants and PCa were evaluated. We identified 102 COI single nucleotide polymorphisms (SNPs), including 15 missense variants. Overall, the presence of one or more COI missense variants was not significantly associated with PCa. Individually, two SNPs (T6221C and T7389C) were significantly associated with prostate cancer (P < 0.05) and in strong linkage disequilibrium with each other (r2 > 0.6). Of the two significantly associated SNPs, one is a synonymous substitution and the other is part of the African-specific mitochondrial haplogroup (L). Additional research will be needed to determine the clinical relevance of these associations in African populations.
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影响因子：
56.9
作者：
Ishikawa, Kaori;Takenaga, Keizo;Hayashi, Jun-Ichi
通讯作者：
Hayashi, Jun-Ichi
影响因子：
9.8
作者：
Pritchard, JK;Rosenberg, NA
通讯作者：
Rosenberg, NA
DOI：
10.1158/1055-9965.epi-08-0434
发表时间：
2008-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Wang L;McDonnell SK;Hebbring SJ;Cunningham JM;St Sauver J;Cerhan JR;Isaya G;Schaid DJ;Thibodeau SN
通讯作者：
Thibodeau SN
DOI：
10.1073/pnas.0408894102
发表时间：
2005-01-18
影响因子：
11.1
作者：
Petros, JA;Baumann, AK;Wallace, DC
通讯作者：
Wallace, DC
影响因子：
30.8
作者：
Quintana-Murci, L;Semino, O;Santachiara-Benerecetti, AS
通讯作者：
Santachiara-Benerecetti, AS