Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions
Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions
复制标题
DOI：
10.1007/s00259-018-4256-0
复制
发表时间：
2019-07-01
影响因子：
9.1
通讯作者：
Carrio, Ignasi
中科院分区：
文献类型：
--
作者：
Fuentes-Ocampo, Francisco;Alfonso Lopez-Mora, Diego;Carrio, Ignasi
PurposeThe目的本研究的目的是评估数字PET/CT中的数字光子计数技术是否会影响靶病变和参考区域的SUVmax定量，与模拟PET/CT相比，在随访研究中可互换使用任一系统之前，MethodsFrom January to June of 2018，100例肿瘤患者在同一天接受了数字和模拟系统的连续PET/CT成像。58例患者先进行模拟成像，然后进行数字成像，42例患者进行数字成像。在每例患者的参考区域（肝脏和纵隔血池）和代谢最活跃的靶病变中测量SUVmax。结果无论PET/CT采集顺序如何，模拟PET/CT和数字PET/CT靶病灶的SUVmax均值分别为8.146.39和9.976.14（P=0.000）。肝脏中的总平均SUVmax，模拟物为4.392.59，数字为4.463.18（P=0.477）。模拟系统和数字系统的纵隔血池中的总平均SUVmax分别为2.30 ± 0.67和2.54 ± 0.74（P=0.000）。第1组：模拟系统靶病变中的平均SUVmax分别为6.64 ± 4.71和9.48 ± 5.60（P=0.000）。模拟物的平均肝脏SUVmax为4.70 +/- 2.90，数字为4.80 +/- 3.72（P=0.088）。模拟系统的纵隔血池SUVmax为2.33 +/- 0.66，数字系统为2.45 +/- 0.73（P=0.041）。第2组：数字系统靶病变的平均SUVmax为10.63 +/- 6.88，模拟系统为10.16 +/- 7.76（P=0.046）。数字式和模拟式的平均肝脏SUVmax分别为3.99 ± 2.20和3.96 ± 2.04（P=0.218）。纵隔血池SUVmax与数字为2.66 +/- 0.75和模拟2.27 +/- 0.68（P=0.000）。两种时间延迟之间无显著差异。在随访研究中互换使用任一系统之前，必须考虑到这一点。
PurposeThe purpose of this study was to assess whether digital photon counting technology in digital PET/CT influences the quantification of SUVmax in target lesions and regions of reference compared to analog PET/CT before an interchangeable use of either system in follow up studies.MethodsFrom January to June of 2018, 100 oncological patients underwent successive PET/CT imaging with digital and analog systems in the same day. Fifty-eight patients underwent analog imaging first and digital imaging thereafter, and 42 patients the other way round. SUVmax was measured in reference regions (liver and mediastinal blood pool) and in the most metabolically active target lesion in each patient. According to the sequence order of PET/CT acquisition, two groups of SUVmax values were obtained, i.e. group 1: analog PET/CT performed first; group 2: digital PET/CT performed first.ResultsMean SUVmax in the total sample (regardless of the order of PET/CT acquisition) in the target lesions with the analog PET/CT was 8.146.39 and the digital 9.976.14 (P=0.000). Total mean SUVmax in the liver with the analog was 4.392.59 and the digital 4.463.18 (P=0.477). Total mean SUVmax in the mediastinal blood pool with the analog was 2.30 +/- 0.67 and the digital 2.54 +/- 0.74 (P=0.000).Group 1: mean SUVmax in the target lesions with the analog system was 6.64 +/- 4.71 and the digital 9.48 +/- 5.60 (P=0.000). Mean liver SUVmax with the analog was 4.70 +/- 2.90 and the digital 4.80 +/- 3.72 (P=0.088). Mediastinal blood pool SUVmax with the analog was 2.33 +/- 0.66 and the digital 2.45 +/- 0.73 (P=0.041).Group 2: mean SUVmax in target lesions with the digital system was 10.63 +/- 6.88 and the analog 10.16 +/- 7.76 (P=0.046). Mean liver SUVmax with the digital was 3.99 +/- 2.20 and the analog 3.96 +/- 2.04 (P=0.218). Mediastinal blood pool SUVmax with the digital was 2.66 +/- 0.75 and the analog 2.27 +/- 0.68 (P=0.000).No significant differences between both time delays were found.ConclusionsImproved photon counting technology in the digital PET/CT, and the effect of delayed increased uptake and retention significantly increases SUVmax values. This has to be taken into account before interchangeable use of either system in follow up studies.