Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
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DOI：
10.1007/s00424-008-0498-1
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发表时间：
2008-09
影响因子：
4.5
通讯作者：
Deen, Peter M. T.
中科院分区：
文献类型：
--
作者：
Boone, Michelle;Deen, Peter M. T.
关键词：
为了防止脱水，陆生动物和人类已经开发出一种敏感而多功能的系统来维持其水平衡。在高钠血症或低血容量状态下，抗利尿激素加压素（AVP）从垂体释放并结合其在肾主细胞中的2型受体。这触发了细胞内cAMP信号级联，其磷酸化水通道蛋白-2（AQP 2）并将通道靶向至顶端质膜。在渗透梯度的驱动下，前尿水通过AQP 2穿过膜，并通过AQP 3和AQP 4水通道离开基底侧的细胞。当水平衡恢复时，AVP水平下降，AQP 2从质膜内化，使质膜再次不透水。AVP的作用被几种激素如前列腺素E2、缓激肽、多巴胺、内皮素-1、乙酰胆碱、表皮生长因子和嘌呤抵消。此外，AQP 2强烈参与以肾浓缩缺陷为特征的疾病以及与严重水潴留相关的病症的病理生理学。本文综述了近年来AVP调节肾脏水转运的分子机制。
To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease.
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影响因子：
8.3
作者：
Alfie, ME;Alim, S;Carretero, OA
通讯作者：
Carretero, OA
DOI：
10.1073/pnas.211191098
发表时间：
2001-10-09
影响因子：
11.1
作者：
Boulter, C;Mulroy, S;Sandford, R
通讯作者：
Sandford, R
DOI：
10.1152/ajprenal.00180.2004
发表时间：
2005-02-01
影响因子：
4.2
作者：
Bustamante, M;Hasler, U;Féraille, E
通讯作者：
Féraille, E
影响因子：
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作者：
CHAMPIGNEULLE, A;SIGA, E;IMBERTTEBOUL, M
通讯作者：
IMBERTTEBOUL, M
影响因子：
4.8
作者：
Charest, Pascale G.;Oligny-Longpre, Genevieve;Bouvier, Michel
通讯作者：
Bouvier, Michel