Age at natural menopause and risk of cardiovascular disease
Age at natural menopause and risk of cardiovascular disease
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DOI：
10.1001/archinte.159.10.1061
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发表时间：
1999-05-24
影响因子：
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通讯作者：
Stampfer, MJ
中科院分区：
文献类型：
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作者：
Hu, FB;Grodstein, F;Stampfer, MJ
目的：在《护士健康研究》中探讨自然绝经年龄与冠心病和卒中风险的关系。方法：对1976~1994年间35 616例绝经后自然绝经妇女进行跟踪调查，这些妇女从未使用过雌激素替代疗法，且未发现心血管疾病。1976年获得绝经状态、绝经年龄和其他危险因素的信息，并通过邮寄问卷每两年更新一次。结果：在354 326人年的随访中，我们记录了757例冠心病和350例中风的发病病例。在调整了年龄、吸烟状况和其他心血管危险因素后，自然更年期不同年龄类别的相对风险(RR)(
Background: Early natural menopause has been postulated to increase the risk of cardiovascular disease.Objective: To examine the relation of age at natural menopause with risk of coronary heart disease (CHD) and stroke in the Nurses' Health Study.Methods: Analysis was restricted to 35 616 naturally postmenopausal women who never used estrogen replacement therapy and with no diagnosed cardiovascular disease at baseline, followed up from 1976 to 1994. Information on menopausal status, age at menopause, and other risk factors was obtained in 1976 and updated every 2 years by mailed questionnaires.Results: During 354 326 person-years of follow-up, we documented 757 incident cases of CHD and 350 incident cases of stroke. After adjusting for age, smoking status, and other cardiovascular risk factors, the relative risks (RRs) across categories of age at natural menopause (