Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice
Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice
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DOI：
10.1128/iai.68.5.2976-2978.2000
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发表时间：
2000-05-01
影响因子：
3.1
通讯作者：
Le Gros, G
中科院分区：
文献类型：
--
作者：
Kirman, J;Zakaria, Z;Le Gros, G
在牛分枝杆菌卡介苗感染的γ干扰素受体缺陷小鼠的肺中观察到肉芽肿的严重嗜酸性粒细胞浸润。通过抗白细胞介素-5单克隆抗体治疗阻断嗜酸性粒细胞增殖和招募进入肺，可略微减少肺内分枝杆菌的生长，但不影响感染向其他组织的传播。
A profound eosinophil infiltration of granulomas is observed in the lungs of Mycobacterium bovis bacillus Calmette Guerin-infected gamma interferon receptor-deficient mice. Blockade of eosinophil proliferation and recruitment into the lung by treatment with anti-interleukin-5 monoclonal antibody marginally reduced mycobacterial growth within the lung but did not affect dissemination of the infection to other tissues.