Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD
Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD
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DOI：
10.1183/09031936.00012408
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发表时间：
2008-10-01
影响因子：
24.3
通讯作者：
Holguin, F.
中科院分区：
文献类型：
--
作者：
Mannino, D. M.;Thorn, D.;Holguin, F.
慢性阻塞性肺疾病（COPD）与重要的慢性合并症有关，包括心血管疾病、糖尿病和高血压。本研究分析了社区动脉粥样硬化风险研究（ARIC）和心血管健康研究（CHS）中20,296名年龄在bb0 = 45岁的受试者的基线数据。根据修改后的全球阻塞性肺疾病倡议（GOLD）标准，根据基线肺功能数据对样本进行分层。然后搜索基线时的合并症、死亡和住院时间超过5年的随访。发现肺功能损害与更多的合并症有关。在调整了年龄、性别、种族、吸烟、体重指数和教育程度的logistic回归模型中，GOLD期3或4期COPD患者的糖尿病患病率（比值比（or） 1.5, 95%置信区间（CI） 1.1-1.9）、高血压患病率（or 1.6, 95% CI 1.3-1.9）和心血管疾病患病率（or 2.4, 95% CI 1.9-3.0）较高。合并症与更高的住院和死亡风险相关，在肺功能受损的人群中情况更糟。肺功能障碍与更高的合并症风险相关，这导致更高的死亡率和住院治疗的不良后果风险。
Chronic obstructive pulmonary disease (COPD) is associated with important chronic comorbid diseases, including cardiovascular disease, diabetes and hypertension.The present study analysed data from 20,296 subjects aged >= 45 yrs at baseline in the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). The sample was stratified based on baseline lung function data, according to modified Global Initiative for Obstructive Lung Disease (GOLD) criteria. Comorbid disease at baseline and death and hospital isations over a 5-yr follow-up were then searched for.Lung function impairment was found to be associated with more comorbid disease. In logistic regression models adjusting for age, sex, race, smoking, body mass index and education, subjects with GOLD stage 3 or 4 COPD had a higher prevalence of diabetes (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1-1.9), hypertension (OR 1.6, 95% CI 1.3-1.9) and cardiovascular disease (OR 2.4, 95% CI 1.9-3.0). Comorbid disease was associated with a higher risk of hospitalisation and mortality that was worse in people with impaired lung function.Lung function impairment is associated with a higher risk of comorbid disease, which contributes to a higher risk of adverse outcomes of mortality and hospital isations.