Attenuated fever response in mice lacking TRPV1
Attenuated fever response in mice lacking TRPV1
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DOI：
10.1016/j.neulet.2004.12.007
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发表时间：
2005-04-11
影响因子：
2.5
通讯作者：
Caterina, M
中科院分区：
文献类型：
--
作者：
Iida, T;Shimizu, I;Caterina, M
辣椒素受体TRPV 1不仅在伤害感受神经元中表达，而且在其他部位也表达，包括下丘脑。涉及全身或下丘脑辣椒素给药的研究表明TRPV 1在体温控制中的作用。为了探索这种可能性，我们研究了TRPV 1-/-小鼠的体温调节反应。这些突变体动物在昼夜体温波动、对升高（35 ℃）或降低（4 ℃）的环境温度或乙醇诱导的低温的耐受性方面没有表现出明显的变化。相反，TRPV 1-/-小鼠对细菌致热原脂多糖（LPS）的发热反应显著减弱。尽管有这一发现，我们检测到TRPV 1-/-和对照小鼠在许多发热相关的脑亚区中LPS诱导的c-Fos表达的程度没有显着差异。这些结果表明，TRPV I参与了多相热的产生，可能在脑外的网站。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrabypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1-/- mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35 degrees C) or decreased (4 degrees C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1-/- mice. Despite this finding, we detected no significant differences between TRPV1-/- and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV I participates in the generation of polyphasic fever, perhaps at sites outside the brain. (c) 2004 Elsevier Ireland Ltd. All rights reserved.