Cellular redox: A modulator of intestinal epithelial cell proliferation
Cellular redox: A modulator of intestinal epithelial cell proliferation
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DOI：
10.1152/nips.01448.2003
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发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Aw, TY
中科院分区：
文献类型：
--
作者：
Aw, TY
粘液增殖、分化和凋亡是肠上皮细胞中持续的稳态过程。谷胱甘肽/谷胱甘肽二硫化物氧化还原状态在肠生长控制中起关键作用，其中降低的氧化还原电位维持增殖状态。这种潜在的氧化转变促进生长停滞和细胞向分化或凋亡表型的转变。
Mucosal proliferation, together with differentiation and apoptosis, are a continuous homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox status plays a key role in intestinal growth control wherein a reduced redox potential maintains a proliferative state. An oxidative shift in this potential elicits growth arrest and cell transition to a differentiated or apoptotic phenotype.