Reproducibility of dual-energy x-ray absorptiometry total and regional body composition measurements using different scanning positions and definitions of regions
Reproducibility of dual-energy x-ray absorptiometry total and regional body composition measurements using different scanning positions and definitions of regions
复制标题
DOI：
10.1016/j.metabol.2009.05.023
复制
发表时间：
2009-11-01
影响因子：
9.8
通讯作者：
Marttinen, Markku T.
中科院分区：
文献类型：
--
作者：
Lohman, Martina;Tallroth, Kaj;Marttinen, Markku T.
在临床工作和研究中经常进行重复双能x射线吸收测量（DEXA）。本研究的目的是研究DEXA全身测量的可重复性，阐明受试者扫描定位的影响，并比较自动和手动定义感兴趣区域（roi）的四肢DEXA测量的可靠性。在测量骨密度的同时，对30名男性志愿者（平均年龄45.2岁）进行了三种DEXA测量，即脂肪组织质量、瘦组织质量（LM）和骨矿物质含量。使用窄扇束Lunar Prodigy密度计（GE Lunar, Madison， WI），对全身进行3次DEXA扫描（2次仰卧，1次俯卧）。对于右臂和右腿的区域测量，在仰卧位和仰卧位下自动和手动设置roi。仰卧位扫描时，全身DEXA测量的骨矿物质含量（r = 0.99）、LM （r = 0.99）、脂肪组织质量（r = 1.00）和骨矿物质密度（r = 0.98）的重复性都很好。从仰卧位到俯卧位的改变稍微降低了全身测量的再现性。局部测量结果的重现性不如全身结果；尤其是上肢，在仰卧位下重复自动测量LM时r值低至0.74，手动调整roi后r值上升至0.93。为了获得成分测量的最大可靠性，我们建议手动检查机器制造的roi，如果需要，手动调整以避免测量误差。(C) 2009爱思唯尔公司版权所有。
Repeated dual-energy x-ray absorptiometry (DEXA) measurements are often performed both in clinical work and in research studies. The aims of the present study were to investigate the repeatability of DEXA total body measurements, to clarify the effect of the scanning positioning of the subject, and to compare the reliability of DEXA measurements of the extremities between automatically and manually defined regions of interest (ROIs). Three DEXA measurements of the total body composition, that is, fat tissue mass, lean tissue mass (LM), and bone mineral content, were performed on 30 male volunteers (mean age, 45.2 years) in addition to measurements of bone mineral density. Using a narrow fan-beam Lunar Prodigy densitometer (GE Lunar, Madison, WI), 3 DEXA scans (2 supine and 1 prone) of the total body were performed. For regional measurements of the right arm and leg, ROIs were set automatically and manually in the supine-supine and supine-prone positions. Repeatability of total body DEXA measurements was excellent for bone mineral content (r = 0.99), LM (r = 0.99), fat tissue mass (r = 1.00), and bone mineral density (r = 0.98) in Supine scanning. Change of position from supine to prone slightly decreased the reproducibility of total body measurements. Reproducibility of regional measurements was inferior to total body results; especially in the upper extremity, the repeated automatic LM measurements in supine-supine positions produced r values as low as 0.74 but increased to 0.93 after manual adjustment of the ROIs. To obtain maximal reliability of the composition measurements, we recommend manual checking of machine-made ROIs and, if needed, manual adjustment to avoid measurement errors. (C) 2009 Elsevier Inc. All rights reserved.