Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer
Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer
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DOI：
10.1111/j.1365-2990.1996.tb00840.x
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发表时间：
1996-02-01
影响因子：
5
通讯作者：
Sutcliffe, JC
中科院分区：
文献类型：
--
作者：
Geddes, JF;Vowles, GH;Sutcliffe, JC
拳击的慢性神经后遗症得到了很好的描述，但很少有关于拳击手在职业生涯早期死亡的神经病理学研究。我们报告了一例23岁的拳击手，他的大脑在所有的新皮质区域都显示出神经原纤维缠结，但内侧颞叶结构的显著保留，这些纠缠被认为是反复头部损伤的结果，是唯一可检测到的异常：在退役拳击手的大脑中没有看到以前描述的其他变化。此病例的神经病理表现的分布和特点提示，反复头部创伤引起的缠结形成机制可能与阿尔茨海默病的机制不同。
The chronic neurological sequelae of boxing are well described, but there have been few neuropathological studies of boxers dying early in their career. We report the case of a 23-year-old boxer, whose brain showed neurofibrillary tangles in all neocortical areas, but remarkable sparing of medial temporal lobe structures, These tangles, assumed to be the result of repetitive head injury, were the only detectable abnormality: none of the other changes previously described in the brains of retired boxers were seen. The distribution and features of the neuropathological findings in this case suggest that the mechanism of tangle formation induced by repetitive head trauma may be different from that in Alzheimer's disease.