The theory of case-control studies for early detection programs.
The theory of case-control studies for early detection programs.
复制标题
早期检测计划的病例对照研究理论。
DOI：
10.1093/biostatistics/4.3.411
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Zelen,Marvin
中科院分区：
文献类型：
--
作者：
Davidov,Ori;Zelen,Marvin
Although case‐control studies are widely used for evaluating the benefit of early detection programs, the theoretical basis underlying this application has not been well developed. In this paper the properties of chronic disease case‐control studies for evaluating early detection programs are investigated. An idealized case‐control study is analyzed and the theoretical expression for the odds ratio associated with the benefit of screening is derived. The odds ratio is related to the natural history of disease and the screening program. Our results indicate that case‐control studies result in odds ratios that are surprisingly close to unity and consequently have low power.
