Desmethylimipramine and the hypotensive action of clonidine in the rabbit.
Desmethylimipramine and the hypotensive action of clonidine in the rabbit.
复制标题
去甲基丙咪嗪和可乐定对兔子的降血压作用。
DOI：
10.1016/0024-3205(73)90215-4
复制
发表时间：
1972
影响因子：
7.3
通讯作者：
J. Reid
中科院分区：
文献类型：
--
作者：
R. Briant;J. Reid
静脉注射去甲基米帕明2.5 mg/kg，可阻断静脉注射可乐定[2-(2，6-二氯苯基)氨基-2-咪唑啉]30μg/kg的降压作用。脑池内注射可乐定1μg/kg的降压作用减弱(对照组平均动脉压下降37.3±2.39 mm Hg；DMI后平均动脉压下降10.2±2.6 7 mm Hg)。DMI后静脉注射去甲肾上腺素引起的急性升压幅度增加(剂量比对照：DMI预处理1：4.3)。这些结果表明，静脉注射和脑池内注射可乐定的降压作用均被抑制神经元摄取去甲肾上腺素的DMI剂量所减弱。
Pretreatment with desmethylimipramine (DMI), 2.5 mg/kg intravenously, abolished the hypotensive action of intravenous clonidine [2-(2,6 dichlorophenyl) amino-2-imidazoline hydrochloride] 30 μg/kg in unanaesthetised normotensive rabbits. The hypotensive action of intracisternal clonidine 1 μg/kg was reduced (mean arterial pressure fall 37.3 ± 2.39 mm Hg in controls; 10.2 ± 2.67 mm Hg after DMI). The magnitude of the acute pressor rise following intravenous noradrenaline was increased after DMI (dose ratio control: DMI pretreated 1:4.3). These results indicate that the hypotensive effect of both intravenous and intracisternal clonidine is reduced by a dose of DMI which inhibits neuronal uptake of noradrenaline.