Performance evaluation of the simplified spherical harmonics approximation for cone-beam X-ray luminescence computed tomography imaging
Performance evaluation of the simplified spherical harmonics approximation for cone-beam X-ray luminescence computed tomography imaging
复制标题
锥束 X 射线发光计算机断层扫描成像简化球谐函数近似的性能评估
DOI：
10.1142/s1793545817500055
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发表时间：
2017
影响因子：
2.5
通讯作者：
He Xiaowei
中科院分区：
文献类型：
--
作者：
Zhang Haibo;Geng Guohua;Chen Yanrong;Zhao Fengjun;Hou Yuqing;Yi Huangjian;Zhang Shunli;Yu Jingjing;He Xiaowei
作为一种新兴的分子成像模式，锥形束 X 射线发光计算机断层扫描 (CB-XLCT) 使用 X 射线可激发探针产生近红外 (NIR) 发光，然后根据表面测量重建探针的三维 (3D) 分布。正确的光子传输模型对于 XLCT 的准确性至关重要。在这里，我们对常用的蒙特卡罗模型和简化球谐函数（SPN）进行了系统的比较。使用已知的 XLCT 材料在几个主要光谱上评估了这两种方法的性能。我们设计了基于余弦相似度的全局测量和局部平均相对误差，以定量评估这些方法。结果表明，SP3对于所有测试的发射光谱都能在建模精度和计算效率之间达到良好的平衡。此外，SP1（相当于扩散方程（DE））可以成为发射波长超过 6...的合理替代模型。
As an emerging molecular imaging modality, cone-beam X-ray luminescence computed tomography (CB-XLCT) uses X-ray-excitable probes to produce near-infrared (NIR) luminescence and then reconstructs three-dimensional (3D) distribution of the probes from surface measurements. A proper photon-transportation model is critical to accuracy of XLCT. Here, we presented a systematic comparison between the common-used Monte Carlo model and simplified spherical harmonics (SPN). The performance of the two methods was evaluated over several main spectrums using a known XLCT material. We designed both a global measurement based on the cosine similarity and a locally-averaged relative error, to quantitatively assess these methods. The results show that the SP3 could reach a good balance between the modeling accuracy and computational efficiency for all of the tested emission spectrums. Besides, the SP1 (which is equivalent to the diffusion equation (DE)) can be a reasonable alternative model for emission wavelength over 6...