Polycaprolactone nanofiber mats decorated with photoresponsive nanogels and silver nanoparticles: Slow release for antibacterial control
Polycaprolactone nanofiber mats decorated with photoresponsive nanogels and silver nanoparticles: Slow release for antibacterial control
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DOI：
10.1016/j.msec.2019.110334
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发表时间：
2020-02-01
影响因子：
7.9
通讯作者：
Zucolotto, Valtencir
中科院分区：
文献类型：
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作者：
Ballesteros, Camilo A. S.;Correa, Daniel S.;Zucolotto, Valtencir
由光激活的智能纳米材料是控制物质在不同环境中释放的最令人兴奋的策略之一。在这里，我们开发了一种智能纳米材料组成的光响应纳米凝胶含有银纳米粒子（AgNps）固定在生物可降解和生物相容性的聚己内酯（PCL）的纳米纤维毡的表面静电纺丝。当该系统被405 nm的光照射时，AgNps从纳米凝胶中释放出来并分散在微球内。这种光激发AgNps的等离子体带，其破坏纳米凝胶，并因此在纳米纤维上释放AgNps。因此，这种AgNps释放机制通过施加光来控制银离子的传播。不同配置的抗菌纳米纤维毡，包括纯PCL纳米纤维和PCL纳米纤维改性与AgNps纳米凝胶和AgNps，在405 nm的激光激发下，关于抗菌性能进行了研究。使用在光暴露后用AgNps和AgNps-纳米凝胶官能化的PCL聚合物实现了最佳结果，其对S产生2.6 +/- 0.3 mm和1.8 +/- 0.5 mm的抑制直径。aureus和E.大肠杆菌中表达。本文所开发的智能纳米材料是一种有前途的光激活伤口敷料临床应用材料。
Smart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial composed by a photoresponsive nanogel containing silver nanoparticles (AgNps) immobilized on the surface of biodegradable and biocompatible polycaprolactone (PCL) nanofibers mats produced by electrospinning. The AgNps are released from the nanogel and dispersed inside the nanofiber mats when this system is irradiated by light at 405 nm. This light excites the plasmonic band of the AgNps, which breaks the nanogel and, as a consequence, releases the AgNps on the nanofibers. Consequently, this AgNps release mechanism controls the propagation of silver ions by the application of light. Different configurations of antibacterial nanofibers mats, including neat PCL nanofibers and PCL nanofibers modified with AgNps-Nanogels and AgNps, excited by laser light at 405 nm, were investigated regarding antibacterial properties. The best result was achieved using PCL nanofiber mats functionalized with AgNps and AgNps-Nanogels after light exposure, which generated inhibition diameters of 2.6 +/- 0.3 mm and 1.8 +/- 0.5 mm for S. aureus and E. coli, respectively. The smart nanomaterial developed here is a promising material for clinical application as wound dressing activated by light.