Pyramidal cells of the frontal lobe: All the more spinous to think with
Pyramidal cells of the frontal lobe: All the more spinous to think with
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DOI：
10.1523/jneurosci.20-18-j0002.2000
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发表时间：
2000-09-15
影响因子：
5.3
通讯作者：
Elston, GN
中科院分区：
文献类型：
--
作者：
Elston, GN
猕猴前额叶10、11和12区锥体细胞的基底树突状动脉通过细胞内注射在固定的、平放的皮质切片中显示。基底树突的大小、分支数量和棘密度被量化，并与枕叶、顶叶和颞叶的锥体细胞进行比较。这些分析显示，额叶的细胞比其他脑叶的细胞更明显地多刺，其刺比初级视觉区（V1）的细胞多16倍，比7a区的细胞多4倍，比TE区的细胞多45%。由于每个树突棘至少接收一个兴奋性输入，大量的棘报告的第三层细胞在前额叶皮质表明，他们能够整合更多的兴奋性输入比第三层锥体细胞迄今为止研究的枕叶，顶叶和颞叶。整合大量兴奋性输入的能力可能对前额皮质神经元的持续紧张性活动特征及其在记忆和认知中的作用很重要。
The basal dendritic arbors of pyramidal cells in prefrontal areas 10, 11, and 12 of the macaque monkey were revealed by intracellular injection in fixed, flat-mounted, cortical slices. The size, number of branches, and spine density of the basal dendrites were quantified and compared with those of pyramidal cells in the occipital, parietal, and temporal lobes. These analyses revealed that cells in the frontal lobe were significantly more spinous than those in the other lobes, having as many as 16 times more spines than cells in the primary visual area (V1), four times more those in area 7a, and 45% more than those in area TE. As each dendritic spine receives at least one excitatory input, the large number of spines reported for layer III cells in prefrontal cortex suggests that they are capable of integrating a greater number of excitatory inputs than layer III pyramidal cells so far studied in the occipital, parietal, and temporal lobes. The ability to integrate a large number of excitatory inputs may be important for the sustained tonic activity characteristic of neurons in prefrontal cortex and their role in memory and cognition.