The painful reality
The painful reality
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DOI：
10.1038/nrd1038
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发表时间：
2003-03
影响因子：
120.1
通讯作者：
Siân Renfrey;Christian Downton;James Featherstone
中科院分区：
文献类型：
--
作者：
Siân Renfrey;Christian Downton;James Featherstone
在可预见的未来，疼痛市场仍然是一个多样化和竞争激烈的市场，有大量的需求未得到满足。预计到2010年，市场规模将超过400亿美元（见图1），我们预计COX2的市场份额将继续增长。新出现的可药物靶点意味着该领域有继续发展的空间（表1）。预计至少有两类新产品将加入到我们的镇痛药库中（表2），包括一氧化氮相关非甾体抗炎药，这类药物预计在2010年的销售额将达到7.5亿美元。随着对疼痛机制的更好理解，量身定制的治疗方法可能比我们想象的更接近真正的疼痛管理，而不是治疗。
For the forseeable future, the pain market remains a varied and competitive market place with significant unmet need. The market is forecast to be over US $40 billion by 2010 (see FIG. 1) and we expect continued growth of the COX2 market share. Novel, emerging druggable targets mean that there is scope for continued development in this sector (TABLE 1). At least two new product classes are forecast to be added to our arsenal to fight pain (TABLE 2), including nitric-oxide-linked NSAIDs, a class that has been predicted to reach US $750 million sales in 2010. With a better understanding of the mechanisms of pain, tailored treatments capable of true pain management—rather than treatment—may be closer than we think.