Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum.
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum.
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在北极熊血清中发现的数百种未识别的卤化污染物。
DOI：
10.1002/anie.201809906
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发表时间：
2018-12-10
期刊：
影响因子：
--
通讯作者：
Martin JW
中科院分区：
文献类型：
--
作者：
Liu Y;Richardson ES;Derocher AE;Lunn NJ;Lehmler HJ;Li X;Zhang Y;Cui JY;Cheng L;Martin JW
北极熊（Ursus maritimus）暴露于持久性有机污染物是在20世纪70年代发现的，但最近的证据表明，它们的血液中存在未知的有毒化学物质。用聚醚砜毛细管搅拌去除蛋白质和磷脂的血清以提取广泛的分析物，并使用具有“碎片标记”的非靶质谱法进行检测。发现了属于13类的数百种分析物，包括新的多氯联苯（PCB）代谢物和许多以前未检测到的氟化或氯化物质。所有分析物中检测到的最古老的（20世纪80年代中期）存档的北极熊血清从哈德逊湾和博福特海，所有氟化类呈上升趋势。一项小鼠实验证实了新的PCB代谢物，表明这些代谢物可能在哺乳动物中广泛存在。历史暴露和毒性风险被低估，新出现的污染物对这一受威胁物种构成不确定的风险。高分辨率质谱分析揭示了北极熊血清中数百种以前未知的卤化污染物。一项小鼠研究证实了5种新的多氯联苯代谢物类别。20世纪80年代中期至2016年期间，多氯联苯代谢物的稳定时间趋势和北极熊血清中氟烷基污染物的增加使得对这些新污染物的毒理学研究成为必要
Exposure of polar bears (Ursus maritimus) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with “fragmentation flagging” was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid-1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and emerging contaminants pose uncertain risks to this threatened species. High resolution mass spectrometry revealed hundreds of previously unknown halogenated contaminants in polar bear serum. A mouse study confirmed the 5 new PCB metabolite classes. Stable time-trends of PCB metabolites and increasing fluoroalkyl contaminants in polar bear serum between the mid-1980s and 2016 make toxicological studies on these new contaminants warranted
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