Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives
Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives
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DOI：
10.1248/cpb.c14-00017
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发表时间：
2014-05-01
影响因子：
1.7
通讯作者：
Sumoto, Kunihiro
中科院分区：
文献类型：
--
作者：
Fujisaki, Fumiko;Aki, Hatsumi;Sumoto, Kunihiro
结合我们对乙酰胆碱衍生物的研究，描述了5-亚甲基乙酰胆碱4a-c到5-氨基甲基取代乙酰胆碱5-10或5-氨基-5-甲基二取代乙酰胆碱11-14的常规区域选择性化学转化。本文还描述了二价双药型海因英衍生物19-24的合成以及二价对称海因英衍生物24b与硫酸糖胺聚糖的结合性质。
In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a-c to 5-aminomethyl-substituted hydantoins 5-10 or to 5-amino-5-methyl-disubstituted hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.