Increases in the 35kDa surfactant‐associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats

Increases in the 35kDa surfactant‐associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats
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胎儿和新生大鼠体内地塞米松治疗后 35kDa 表面活性剂相关蛋白及其 mRNA 增加

DOI:
10.1002/elps.1150080506
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发表时间:
1987
期刊:
影响因子:
2.9
通讯作者:
J. Floros
J. Floros
中科院分区:
生物学3区
文献类型:
--
作者:
D. Phelps;S. Church;S. Kourembanas;H. Taeusch;J. Floros

文献摘要

参考文献

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用地塞米松处理胎鼠和新生大鼠,观察地塞米松对胎鼠和新生大鼠肺表面活性物质相关蛋白35 kDa的影响。地塞米松治疗增加了35 kDa蛋白的可翻译mRNA水平,从妊娠第19天到出生后至少6天。在妊娠19天之前,虽然早在妊娠16天就能检测到该基因,但没有观察到糖皮质激素效应。免疫沉淀和双向凝胶电泳法检测到[35S]蛋氨酸标记的35 kDa蛋白也有类似的结果。
Fetal and neonatal rats were treated with dexamethasone in vivo and the effect of this treatment on the 35kDa surfactant‐associated protein was examined. Dexamethasone treatment increased the levels of translatable mRNA for the 35kDa protein from day 19 of gestation until at least 6 days after birth. Prior to gestational day 19, no glucocorticoid effect was seen although the mRNA was detectable as early as gestational day 16. Similar results were seen when [35S]methionine‐labeled 35kDa protein was immunoprecipitated and subjected to two‐dimensional gel electrophoresis.
糖皮质激素在翻译前水平影响肺成纤维细胞-肺细胞因子的合成。
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
Floros,J;Post,M;Smith,BT
通讯作者: Smith,BT
DOI: 10.1016/0167-4838(86)90073-7
发表时间: 1986-02-14
期刊: BIOCHIMICA ET BIOPHYSICA ACTA
影响因子: --
作者:
WEAVER, TE;HULL, WM;WHITSETT, JA
通讯作者: WHITSETT, JA
人肺主要表面活性剂相关蛋白的生物合成和体外翻译。
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
Floros,J;Phelps,DS;Taeusch,HW
通讯作者: Taeusch,HW
大鼠体内主要表面活性蛋白的初级翻译产物、生物合成和组织特异性。
DOI: --
发表时间: 1986
期刊: The Journal of biological chemistry
影响因子: --
作者:
Floros,J;Phelps,DS;Kourembanas,S;Taeusch,HW
通讯作者: Taeusch,HW
胎兔肺组织中主要表面活性剂脱辅基蛋白合成的调节。
DOI: --
发表时间: 1986
期刊: The Journal of biological chemistry
影响因子: --
作者:
Mendelson,CR;Chen,C;Boggaram,V;Zacharias,C;Snyder,JM
通讯作者: Snyder,JM