Determinants of serum total and free testosterone levels in women over the age of 65 years
Determinants of serum total and free testosterone levels in women over the age of 65 years
复制标题
DOI：
10.1210/jc.2006-1399
复制
发表时间：
2007-02-01
影响因子：
5.8
通讯作者：
Fried, Linda P.
中科院分区：
文献类型：
--
作者：
Cappola, Anne R.;Ratcliffe, Sarah J.;Fried, Linda P.
内容：很少有人知道睾丸激素（T）水平和他们的决定因素在妇女的后期postmenopauseages.Objective：我们描述水平的总和游离T和选定的因素，影响这些水平的随机样本的老年妇女。设计：采用微透析法测定了347名65岁至69岁的社区妇女血清总T和游离T水平。参加心血管健康研究的98岁患者。结果：在调整后的模型中：1）总T水平随年龄增长而下降，但游离T水平不随年龄变化，2）双侧卵巢切除的妇女总T水平比至少一个卵巢完整的妇女低23%，游离T水平比至少一个卵巢完整的妇女低16%;（3）口服雌激素者的总T和游离T水平比从不服用雌激素者低47%;（4）肥胖妇女的总T和游离T水平比正常体重妇女高47%和20%，超重妇女的总T和游离T水平比正常体重妇女高24%和14%; 5）黑人妇女的游离T水平高出51%。皮质类固醇使用者有75%的总T和43%的游离T水平低于nonusers.Conclusions：双侧卵巢切除术，雌激素的使用，皮质类固醇的使用，低体重指数是独立的危险因素，为65岁及以上的妇女T水平较低。虽然在这个年龄段的妇女中非常普遍，但在绝经后期妇女中低T水平的生理意义需要进一步研究。
Context: Little is known about testosterone ( T) levels and their determinants in women of late postmenopausal age.Objective: We describe levels of total and free T and selected factors that influence these levels in a random sample of older women.Design: Levels of serum total T and free T by microdialysis were measured using ultrasensitive assays in 347 community-dwelling women aged 65-98 yr enrolled in the Cardiovascular Health Study. Cross-sectional analyses were performed to define factors associated with total and free T levels.Results: In adjusted models: 1) total T levels declined with age until 80, whereas free T levels did not vary by age; 2) women with bilateral oophorectomy had 23% lower total T and 16% lower free T levels than those with at least one intact ovary; 3) oral estrogen users had total and free T levels that were 47% lower than never users; 4) obese women had 47% higher total T and 20% higher free T levels, and overweight women had 24% higher total T and 14% higher free T levels, than normal weight women; and 5) free T levels were 51% higher in black women. Corticosteroid users had 75% lower total T and 43% lower free T levels than nonusers.Conclusions: Bilateral oophorectomy, estrogen use, corticosteroid use, and low body mass index are independent risk factors for lower T levels in women aged 65 yr and over. Although highly prevalent in women of this age, the physiological significance of low T levels in late postmenopausal women requires further investigation.