Palladium-catalyzed C-H bond carboxylation of acetanilides: an efficient usage of N,N-dimethyloxamic acid as the carboxylate source
Palladium-catalyzed C-H bond carboxylation of acetanilides: an efficient usage of N,N-dimethyloxamic acid as the carboxylate source
复制标题
钯催化乙酰苯胺的 C-H 键羧化：有效使用 N,N-二甲基肟酸作为羧酸盐源
DOI：
10.1039/c5cc07890c
复制
发表时间：
2016
影响因子：
4.9
通讯作者：
Luo Hai-Bin
中科院分区：
文献类型：
--
作者：
Wu Yinuo;Jiang Cheng;Wu Deyan;Gu Qiong;Luo Zhang-Yi;Luo Hai-Bin
N，N-二甲基肟酸可以成功地作为羧酸前体用于钯催化乙酰苯胺直接C-H羧化反应。该反应在温和的条件下顺利进行，在广泛的底物上具有高官能团耐受性，提供中高产量的取代n -酰基邻氨基苯酸。
N,N-Dimethyloxamic acid can be successfully employed as a carboxylate precursor in the palladium-catalyzed direct C–H carboxylation of acetanilides. The reaction proceeds smoothly under mild conditions over a broad range of substrates with high functional group tolerance, affording substituted N-acyl anthranilic acids in moderate to high yields.