Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study
Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study
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DOI：
10.1111/jsr.12125
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发表时间：
2014-06-01
影响因子：
4.4
通讯作者：
Nolte, Ingo
中科院分区：
文献类型：
--
作者：
Bumb, Jan M.;Schilling, Claudia;Nolte, Ingo
关于松果体体积和失眠之间的关系知之甚少。褪黑激素促进睡眠过程，并且作为药物施用，它适合于改善人类的原发性和继发性睡眠障碍。最近的磁共振成像研究表明，人体血浆和唾液褪黑激素水平部分取决于松果体体积。本研究比较了一组原发性失眠症患者和一组无睡眠障碍的健康人的松果体体积。在高分辨率3特斯拉MRI（T1磁化准备的快速梯度回波）的基础上，测量了23例患者和27例对照组的松果体体积（PGV），年龄，性别和教育状况相匹配。体积测量常规进行手动划定松果体边界的多平面重建图像。松果体体积明显减小（P
Little is known about the relation between pineal volume and insomnia. Melatonin promotes sleep processes and, administered as a drug, it is suitable to improve primary and secondary sleep disorders in humans. Recent magnetic resonance imaging studies suggest that human plasma and saliva melatonin levels are partially determined by the pineal gland volume. This study compares the pineal volume in a group of patients with primary insomnia to a group of healthy people without sleep disturbance. Pineal gland volume (PGV) was measured on the basis of high-resolution 3 Tesla MRI (T1-magnetization prepared rapid gradient echo) in 23 patients and 27 controls, matched for age, gender and educational status. Volume measurements were performed conventionally by manual delineation of the pineal borders in multi-planar reconstructed images. Pineal gland volume was significantly smaller (P