Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3.
Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3.
复制标题
DOI：
10.1677/erc-09-0023
复制
发表时间：
2010-03
影响因子：
3.9
通讯作者：
Blot WJ
中科院分区：
文献类型：
--
作者：
Fowke JH;Matthews CE;Yu H;Cai Q;Cohen S;Buchowski MS;Zheng W;Blot WJ
非裔美国人(AA)种族/民族、较低的体重指数(BMI)和较高的胰岛素样生长因子-1(IGF-1)水平与绝经前乳腺癌风险相关。这项横断面分析调查了21岁时的BMI或BMI是否导致IGF-1、IGF-2、IGFBP-3或游离IGF-1的种族差异。参与者包括816名白人和821名AA女性，年龄在40岁到79岁之间，体重指数范围很大(18.5-40公斤/平方米)。与白人妇女相比，再生障碍性贫血妇女的平均胰岛素样生长因子-1(146.3对134.4 ng/ml)和游离胰岛素样生长因子-1(0.145对0.127)水平较高，而胰岛素样生长因子-2(1633.0对1769.3 ng/ml)和胰岛素样生长因子结合蛋白-3(3663.3对3842.5 ng/ml)水平较低(均P<；0.01；调整了年龄、身高、体重指数、21岁时的体重指数和更年期状态)。无论种族，IGF-1和游离IGF-1水平随着BMI增加到22-24 kg/m2而急剧上升，然后下降，而IGF-2和IGFBP-3水平则随着BMI的增加而呈上升趋势。相反，21岁时的BMI与所有IGF水平呈负相关，但仅限于白人女性(p-交互作用=0.01)。随着21岁白人IGF-1和BMI的下降，在成年早期肥胖的女性中，IGF-1的种族差异显著增加。总而言之，BMI与IGF-1水平有关，无论种族/民族，而儿童时期或青年时期的肥胖可能对白人女性的IGF-1水平有更大的影响。终生肥胖对IGF轴的影响以及乳腺癌风险的种族差异需要研究。
African American (AA) race/ethnicity, lower body mass index (BMI), and higher insulin-like growth factor 1 (IGF-1) levels are associated with premenopausal breast cancer risk. This cross-sectional analysis investigated whether BMI or BMI at age 21 years contribute to racial differences in IGF-1, IGF-2, IGFBP-3, or free IGF-1. Participants included 816 white and 821 AA women between ages 40 and 79 years across a wide BMI range (18.5–40 kg/m2). Compared with white women, AA women had higher mean IGF-1 (146.3 vs. 134.4 ng/ml) and free IGF-1 (0.145 vs. 0.127) levels, and lower IGF-2 (1633.0 vs. 1769.3 ng/ml) and IGFBP-3 (3663.3 vs. 3842.5 ng/ml) levels (all p<0.01; adjusted for age, height, BMI, BMI at age 21, and menopause status). Regardless of race, IGF-1 and free IGF-1 levels sharply rose as BMI increased to 22–24 kg/m2, then declined thereafter, while IGF-2 and IGFBP-3 levels tended to rise with BMI. In contrast, BMI at age 21 was inversely associated with all IGF levels, but only among white women (p-interaction = 0.01). With the decline in IGF-1 with BMI at age 21 among whites, racial differences in IGF-1 significantly increased among women who were obese in early adulthood. In summary, BMI was associated with IGF-1 levels regardless of race/ethnicity, while obesity during childhood or young adulthood may have a greater impact on IGF-1 levels among white women. The effects of obesity throughout life on the IGF axis and racial differences in breast cancer risk require study.