Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells.
Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells.
复制标题
白介素4抵消了白介素2诱导的单克隆B细胞增殖。
DOI：
10.1084/jem.168.1.85
复制
发表时间：
1988-07-01
影响因子：
15.3
通讯作者：
Galanaud, P
中科院分区：
文献类型：
--
作者：
Karray, S;DeFrance, T;Merle-Beral, H;Banchereau, J;Debre, P;Galanaud, P
来自患有B型慢性淋巴细胞白血病（B-CLL）的患者的B细胞对几种白细胞介素的作用敏感。使用来自12个不同患者的细胞，我们表明IL-4不与抗mu抗体协同增强DNA合成。此外，IL-4极大地（90%）抑制了10名对这种白细胞介素有反应的患者对IL-2的反应。无论IL-2单独使用、与抗μ抗体共刺激还是与IFN-γ协同使用，都会发生这种抑制。在任何情况下，IL-4诱导终末分化。IL-4的这种负面作用可以发生在单克隆B-CLL细胞中，其中IL-4增强CD23的表达。IL-4不干扰IL-2对CD25的上调。因此，IL-4可对所选B细胞群的增殖反应显示抑制作用。IL-4和IL-2之间的拮抗作用对于细胞因子在B-CLL患者的管理中的潜在用途具有重要意义。
B cells from patients suffering from B-type chronic lymphocytic leukemia (B-CLL) are susceptible to the effects of several interleukins. Using the cells from 12 different patients we show that IL-4 does not synergize with anti-mu antibody for the enhancement of DNA synthesis. Moreover IL-4 profoundly (90%) suppresses the response to IL-2 in the 10 patient responders to this interleukin. This suppression occurs whether IL-2 is used alone, in costimulation with anti-mu antibody, or in synergy with IFN-gamma. In no instance did IL-4 induce terminal differentiation. This negative effect of IL-4 can take place in monoclonal B-CLL cells where IL-4 enhances the expression of CD23. IL-4 does not interfere with the upregulation of CD25 by IL-2. Thus, IL-4 may display inhibitory effects on the proliferative response of selected B cell populations. The antagonism between IL-4 and IL-2 has important implications for the potential use of cytokines in the management of B-CLL patients.