Classification of pancreatic cancer (nonendocrine).
Classification of pancreatic cancer (nonendocrine).
复制标题
胰腺癌的分类（非内分泌癌）。
DOI：
--
复制
发表时间：
1979
影响因子：
8.9
通讯作者：
P. Fitzgerald
中科院分区：
文献类型：
--
作者：
A. Cubilla;P. Fitzgerald
从1949年至1972年期间在纪念医院登记的757名胰腺癌患者的记录中，有508名患者的临床资料和病理组织可供研究。对这些病例的审查导致组织学分类为11个亚类和1个未分类组。最常见的类型是导管细胞腺癌（75%），其余亚组各占总数的不到5%。除了一种亚型外，所有亚型都是发生在其他器官中的众所周知的癌模式。一种小腺癌，即微腺癌，通常与胰腺无关。某些类型的肿瘤在诊断后存活期较短，仅为几个月，例如导管细胞癌、巨细胞癌、腺泡细胞癌、腺鳞癌和微腺癌。粘液性癌患者的平均生存期延长了几个月，少数粘液性囊腺癌患者的中位生存期更长。提到并说明了两种罕见类型--乳头状囊性肿瘤和胰母细胞瘤。希望这些类型中的一种或多种可以与病原体，一些临床特征或对治疗方案的反应性相关。
From the records of 757 patients listed as having had pancreatic cancer at Memorial Hospital during the years 1949 through 1972, adequate clinical data and pathologic tissue were available for study in 508 patients. Review of these cases led to a histologic classification into 11 subcategories and one unclassified group. The most common type was the duct cell adenocarcinoma (75%), and the remaining subgroups each made up less than 5% of the total. All except one of the subtypes were well-known carcinoma patterns that occur in other organs. A small-gland carcinoma, the microadenocarcinoma, has not usually been associated with the pancreas. Some types were associated with short survival periods of a few months after diagnosis--for example, duct cell, giant cell, acinar cell, and adenosquamous carcinomas and microadenocarcinoma. Patients with mucinous carcinoma had a mean survival period of a few months longer, and the few patients with mucinous cystadenocarcinoma had a much longer median survival. Two rare types--papillary cystic tumor and pancreaticoblastoma--are mentioned and illustrated. It is hoped that one or more of these types can be associated with an etiologic agent, some clinical feature, or responsiveness to a therapeutic regimen.