Correlation of BMI with breast cancer subtype and tumour size.
Correlation of BMI with breast cancer subtype and tumour size.
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DOI：
10.3332/ecancer.2018.845
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发表时间：
2018
影响因子：
1.8
通讯作者：
Kumar RV
中科院分区：
文献类型：
--
作者：
Govind Babu K;Anand A;Lakshmaiah KC;Lokanatha D;Jacob LA;Suresh Babu MC;Lokesh KN;Rudresha HA;Rajeev LK;Saldanha SC;Giri GV;R C;Koppaka D;Panwar D;Kumar RV
乳腺癌是一种异质性疾病，根据分子水平可分为腔型、HER2型和基底型。体重指数(BMI)增加与患乳腺癌的风险有关，但基于分子亚型的关联仍然相互矛盾。这是一项为期两年的观察性研究。根据替代标记物(ER、PR和HER2)评估非转移性乳腺癌患者的肿瘤亚型。这些患者的BMI与肿瘤的亚型和大小相关。我们研究了476例乳腺癌患者，中位年龄46岁(范围25-86岁)，其中58%为绝经前。队列的平均BMI为24.1，绝经后女性的BMI显著高于后者(24.9比23.6，p<；0.05)。总体而言，只有10%的患者肥胖。鲁米那、HER2和TNBC亚型的平均BMI分别为24.7、22.4和23.9(p<；0.01)。腔内、HER2和TNBC亚型的肿瘤平均直径分别为4.02、3.8和4.27 cm(p=0.158)。诊断时，平均BMI在管腔亚型患者中较高，其次是TNBC，而在HER2亚型患者中最低。TNBC的平均肿瘤大小在数值上高于HER2亚型，而HER2亚型的平均肿瘤大小最小，尽管差异不具有统计学意义。更大规模的研究可能会明确BMI和肿瘤亚型之间的联系。
Breast cancer is a heterogeneous disease which is divided broadly into luminal, HER2 and basal type based on molecular profiling. Increased body mass index (BMI) has been associated with the risk of developing breast cancer but the association based on molecular subtype remains conflicting. This was an observational study carried out over a period of 2 years. Nonmetastatic breast cancer patients were evaluated for the tumour subtype based on surrogate markers (ER, PR and HER2). The BMI of these patients was correlated with the tumour subtype and size. We studied 476 patients with breast cancer with the median age of 46 years (range, 25–86) and 58% were premenopausal. The mean BMI of the cohort was 24.1, which was significantly higher in postmenopausal women (24.9 versus 23.6, p < 0.05). Overall, only 10% of patients were obese. The mean BMI in the luminal, HER2 and TNBC subtypes was 24.7, 22.4 and 23.9, respectively (p < 0.01). Also, the mean tumour size in luminal, HER2 and TNBC subtype was 4.02, 3.80 and 4.27 cm, respectively (p = 0.158). The average BMI was higher in patients with luminal subtype followed by TNBC and lowest for HER2 at the time of diagnosis. The mean tumour size was numerically higher for TNBC and lowest for HER2 subtype although the difference was not statistically significant. Larger studies may provide clarity of association between the BMI and tumour subtype.