CSF corticotropin-releasing factor in personality disorder: Relationship with self-reported parental care
CSF corticotropin-releasing factor in personality disorder: Relationship with self-reported parental care
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DOI：
10.1038/sj.npp.1301104
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发表时间：
2006-10-01
影响因子：
7.6
通讯作者：
Coccaro, Emil F.
中科院分区：
文献类型：
--
作者：
Lee, Royce J.;Gollan, Jackie;Coccaro, Emil F.
本横断面调查测试了有和无人格障碍（PD）的成年人自我报告的儿童期父母照顾水平与脑脊液（CSF）促肾上腺皮质激素释放因子（CRF）浓度之间的关系。基于产后父母护理对中央CRF功能的持久影响的临床前模型，主要假设是儿童期父母护理（如父母结合量表（PBI）护理和参与子量表所反映的）与成人CSF CRF水平呈负相关。样本包括来自19名受试者的脑脊液CRF样本，这些受试者被纳入先前发表的关于CRF水平与儿童创伤问卷评分之间关系的报告中。在54名无药物治疗的男性和女性受试者中，采用PBI回顾性测量了父母关系，其中37名被诊断为DSM-IV PD，其中17名为无轴I和II精神病理学的正常对照。将通过腰椎穿刺测量的CSF CRF水平作为因变量输入模型，自变量为PBI父母护理和参与、诊断类别、年龄和性别。预测CSF CRF水平的模型是显着的，PBI父母的照顾和参与与CSF CRF水平呈负相关。高于中位PBI父母照顾和参与评分的PD受试者的CSF CRF水平显著低于正常对照组和低于中位PBI父母照顾和参与评分的PD受试者。更高水平的自我报告父母护理预测PD受试者的CSF CRF水平较低，这与父母护理对降低应激反应的有益作用一致，也与既往人类报告一致。然而，这项研究的横断面设计限制了因果关系的推断。
This cross-sectional investigation tests the relationship between the level of self-reported childhood parental care and cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentration in adults with and without personality disorder (PD). Based on preclinical models of the lasting effect of post-natal parental care on central CRF function, the primary hypothesis was that childhood parental care, as reflected by the parental bonding inventory (PBI) care and involvement subscale, is inversely correlated with adult CSF CRF levels. The sample includes cerebrospinal fluid CRF samples from 19 subjects who were included in a previously published report on the relationship between CRF level and Childhood Trauma Questionnaire score. Parental bonding was measured retrospectively with the PBI in 54 medication-free male and female subjects, 37 of whom were diagnosed with a DSM-IV PD, 17 of whom were normal controls free of Axis I and II psychopathology. CSF CRF level as measured by lumbar puncture was entered into a model as the dependent variable, with the independent variables of PBI Parental Care and Involvement, diagnostic category, age, and gender. The model predicting CSF CRF level was significant, with PBI parental care and involvement negatively correlated with CSF CRF level. PD subjects with higher than median PBI parental care and involvement score had significantly lower CSF CRF levels than both normal controls and PD subjects with lower than median PBI parental care and involvement. Higher levels of self-report parental care predict lower CSF CRF levels in PD subjects, consistent with a beneficial effect of parental care on decreased stress reactivity, and consistent with previous reports in humans. The cross-sectional design of the study, however, limits causal inferences.