Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity
Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity
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DOI：
10.1016/s0166-4328(01)00445-4
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发表时间：
2002-06-15
影响因子：
2.7
通讯作者：
Leung, LS
中科院分区：
文献类型：
--
作者：
Ma, JY;Leung, LS
本实验研究了代谢型谷氨酸受体(MGluR)亚型在自由行为大鼠海马脑电(30-100 Hz)产生和后放电(AD)行为中的作用。海马区AD引起伽马波(30-100赫兹)增加20min，并伴有行为多动。双侧脑室内(I.C.V.)I组和11mGluR拮抗剂(RS)-α-甲基-4-羧基苯甘氨酸(MCPG)可显著抑制AD大鼠的伽马波增加和行为多动。MCPG不影响海马theta节律、自发的海马伽马波和类似于40赫兹的诱发场电位振荡。输液前(i.c.v.)(2S)-α-乙基谷氨酸(Eglu，11组mGluR拮抗剂)，而(RS)-1-氨基吲哚-1，5-二羧酸(AIDA，I组mGluR拮抗剂)可抑制海马伽马波和行为的增加。MCPG被局部注入不同的脑结构，以确定其靶点。海马内注射MCPG，或称EGLU，可阻断伽马波和行为的增加。伏隔核内注射MCPG可抑制大鼠的行为多动，但不影响海马伽马波的增加。内侧隔区注射MCPG既不能阻断大脑皮质后伽玛活动，也不能阻断行为多动。提示海马区11mGluRs参与了海马后伽玛波的产生，而伏隔核内mGluRs参与了行为性多动的产生。然而，正常海马区的自发伽马和theta波不是由mGluRs介导的。(C)2002 Elsevier Science B.V.保留所有权利。
The involvement of metabotropic glutamate receptor (mGluR) subtypes in the generation of hippocampal EEG (30-100 Hz) and behaviors induced by a hippocampal afterdischarge (AD) was examined in freely behaving rats. A hippocampal AD induced an increase in gamma waves (30-100 Hz) for 20 min, accompanied by behavioral hyperactivity. Bilateral intracerebroventricular (i.c.v.) infusion of (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a group I and 11 mGluR antagonist, 30 min before a hippocampal AD, significantly suppressed both the increase in gamma waves and the behavioral hyperactivity. The hippocampal theta rhythm, the spontaneous hippocampal gamma waves, and evoked field potential oscillations of similar to 40 Hz were not affected by MCPG. Pre-infusion (i.c.v.) of (2S)-alpha-ethylglutamic acid (EGLU; a group 11 mGluR antagonist), but not (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; a group I mGluR antagonist), suppressed the postictal increase of both hippocampal gamma waves and behaviors. MCPG was infused locally into different brain structures in order to specify its target sites. Intra-hippocampal infusion of MCPG, or EGLU, blocked the increase in both gamma waves and behaviors. Infusion of MCPG into the nucleus accumbens suppressed the postictal behavioral hyperactivity without affecting the increase in hippocampal gamma waves. MCPG injected into the medial septum blocked neither postictal gamma activity nor behavioral hyperactivity. It is suggested that the group 11 mGluRs in the hippocampus are involved in generation of the postictal hippocampal gamma waves, while behavioral hyperactivity is partly mediated by mGluRs in the nucleus accumbens. However, spontaneous gamma and theta waves in the normal hippocampus are not mediated by mGluRs. (C) 2002 Elsevier Science B.V. All rights reserved.