The anti-inflammatory effects of phlorotannins from Eisenia arborea on mouse ear edema by inflammatory inducers.
The anti-inflammatory effects of phlorotannins from Eisenia arborea on mouse ear edema by inflammatory inducers.
复制标题
树爱胜蚓中的叶皮单宁对炎症诱导剂引起的小鼠耳水肿的抗炎作用。
DOI：
10.1016/j.jff.2013.08.010
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
K. Imai and T. Matsushita
中科院分区：
文献类型：
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作者：
Y. Sugiura;R. Tanaka;H. Katsuzaki;K. Imai and T. Matsushita
在体外实验中已经报道了褐藻爱森尼藻多酚（海藻多酚）的抗过敏和抗炎作用。因此，在本研究中，这些影响在活体小鼠中进行了检验。花生四烯酸（AA）、12- o -十四烷酚-13-乙酸酯（TPA）和恶唑酮（OXA） 3种增敏剂致ICR小鼠耳水肿后，4种绿鞣素（eckol、8,8′-bieckol、PFF -A和PFF- b）分别在小鼠耳上涂抹0.01或0.1 mg后，均能抑制小鼠耳水肿。AA和OXA处理后绿丹素对耳部水肿的抑制作用强于TPA处理，对各增敏剂的抑制作用与典型抑制剂表没食子儿茶素没食子酸酯相似。这是第一次报道在体内实验中，紫丹素表现出抗过敏和抗炎作用，并抑制oxa诱导的延迟型（IV型）过敏反应。
The anti-allergic and anti-inflammatory effects of phlorotannins (seaweed polyphenols) from the brown algaEisenia arboreausingin vitroexperiments has already been reported. Therefore, in this study, these effects were examinedin vivousing mice. When ear edema was induced in ICR mice by three sensitizers (arachidonic acid (AA), 12-O-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)), four phlorotannins tested (eckol, 8,8’-bieckol, phlorofucofuroeckol (PFF)-A and PFF-B) inhibited the ear edema after spreading of 0.01 or 0.1 mg onto the mouse ear. The effects of the phlorotannins on the ear edema after AA and OXA treatments tended to be stronger than after TPA treatment, and the inhibitory effects against each sensitizer were similar to epigallocatechin gallate, a typical inhibitor. This is the first report that phlorotannins exhibit anti-allergic and anti-inflammatory effects inin vivoexperiments, and inhibit OXA-induced delayed-type (type IV) allergic reactions.