Pathophysiology, epidemiology, and natural history of benign prostatic hyperplasia.
Pathophysiology, epidemiology, and natural history of benign prostatic hyperplasia.
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发表时间：
2004
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通讯作者：
H. Lepor
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作者：
H. Lepor
良性前列腺增生（BPH）的病理生理学、流行病学和自然史尚不完全清楚;然而，可靠的测量症状严重程度、前列腺肿大和膀胱出口梗阻的工具的发展使其阐明取得了重大进展。老年男性下尿路症状（LUTS）的发生在一定程度上受膀胱出口梗阻和前列腺肥大的严重程度的影响。虽然LUTS、膀胱出口梗阻和BPH的发展是年龄依赖性的，但它们不一定是因果关系;还有许多其他因素参与了LUTS的病理生理学。在患有中度至重度LUTS和低峰值流速的男性中，疾病进展的临床重要参数是症状进展和急性尿潴留（AUR）的发生。AUR的风险与基线血清前列腺特异性抗原水平和前列腺体积有关。在中度前列腺肥大的男性中，AUR的风险似乎很高，足以证明5 α还原酶抑制剂的干预，以降低这种风险。
The pathophysiology, epidemiology, and natural history of benign prostatic hyperplasia (BPH) are incompletely understood; however, the development of reliable instruments to measure symptom severity, prostatic enlargement, and bladder outlet obstruction has allowed major advances in their elucidation. The development of lower urinary tract symptoms (LUTS) in the aging male is influenced to some degree by the severity of bladder outlet obstruction and prostatic enlargement. Although the development of LUTS, bladder outlet obstruction, and BPH are age-dependent, they are not necessarily causally related; there are many other factors involved in the pathophysiology of LUTS. The clinically important parameters of disease progression in men with moderate to severe LUTS and low peak flow rates are symptom progression and the development of acute urinary retention (AUR). The risk of AUR is related to both baseline serum prostate-specific antigen level and prostate volume. In men with moderate prostate enlargement, the risk of AUR appears to be high enough to justify intervention with a 5alpha-reductase inhibitor in order to reduce this risk.