Humanized mice as a model for rheumatoid arthritis.
Humanized mice as a model for rheumatoid arthritis.
复制标题
人源化小鼠作为类风湿关节炎的模型。
DOI：
10.1186/ar580
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Sønderstrup G
中科院分区：
文献类型：
--
作者：
Eming R;Visconti K;Hall F;Sekine C;Kobayashi K;Chen Q;Cope A;Kanazawa S;Peterlin M;Rijnders A;Boots A;Meijerink J;Sønderstrup G
Genetic susceptibility to rheumatoid arthritis (RA), a common autoimmune disease, is associated with certain HLA-DR4 alleles. Treatments are rarely curative and are often tied to major side effects. We describe the development of a humanized mouse model wherein new, less toxic, vaccine-like treatments for RA might be pretested. This model includes four separate transgenes: HLA-DR*0401 and human CD4 molecules, a RA-related human autoantigenic protein (HCgp-39), and a T-cell receptor (TCRαβ) transgene specific for an important HCgp-39 epitope, eliciting strong Th1 responses in the context of HLA-DR*0401.
