Nanotechnology in Neuroscience Reveals Membrane Mobility Matters.
Nanotechnology in Neuroscience Reveals Membrane Mobility Matters.
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神经科学中的纳米技术揭示了膜流动性的重要性。
DOI：
10.1021/acschemneuro.8b00495
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发表时间：
2019
影响因子：
5
通讯作者：
Rosenthal,SandraJ
中科院分区：
文献类型：
--
作者：
Rosenthal,SandraJ
量子点是纳米级的半导体，具有尺寸可调、发射带窄、量子产率高、耐光漂白等特点。配体共轭量子点能够实现膜蛋白的实时可视化，并揭示了膜扩散动力学是蛋白质调节的内在特征，易受膜胆固醇水平的影响，并在与疾病相关的遗传变异中发生改变，这表明了神经精神药理学的一种原位方法。
Quantum dots are nanometer-sized semiconductors that have size-tunable, narrow emission bands, high quantum yields, and are resistant to photobleaching. Ligand-conjugated quantum dots enable the real time visualization of membrane proteins and have revealed that membrane diffusion dynamics are intrinsic to protein regulation, are susceptible to the level of membrane cholesterol, and are altered in genetic variants linked to disease, suggesting amise en placeapproach to neuropsychopharmacology.