Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
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DOI：
10.1016/s0167-8140(03)00081-1
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发表时间：
2003-06-01
影响因子：
5.7
通讯作者：
Overgaard, J
中科院分区：
文献类型：
--
作者：
Bentzen, L;Keiding, S;Overgaard, J
背景和目的：本研究的目的是使用缺氧标记物[F-18]-氟米索硝唑（[F-18]FMISO）和侵入性氧敏感探针（Eppendorf pO(2) Histograph，德国）通过 PET 扫描来识别人类软组织肉瘤（STS）中的缺氧情况。 材料和方法：通过 [F-18]FMISO PET 扫描对 13 名疑似 STS 的肿瘤患者进行了检查，其中 11 名患者接受了 [F-18]FMISO PET 扫描检查。患者在扫描后完成了一组 Eppendorf PO2 直方图测量。结果和讨论：通过组织病理学诊断，7 个肿瘤显示为 STS，6 个肿瘤为良性。在指定的感兴趣区域检查肿瘤和肌肉放射性之间的比率以及肿瘤和肌肉组织的时间活性曲线。随着时间的推移，只有两种恶性肿瘤显示 [F-18]FMISO 摄取量高于肌肉组织。通过氧电极法测量，良性和恶性肿瘤中均存在缺氧。结论：在我们的环境中，[F-18]FMISO PET 似乎不适用于检测人类软组织肿瘤中的肿瘤缺氧。它也反映了氧电极测量确定的缺氧程度。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Background and purpose: The aim of the study was to identify hypoxia in human soft tissue sarcomas (STS) by PET scanning using the hypoxia marker [F-18]-fluoromisonidazole ([F-18]FMISO) and invasive oxygen sensitive probes (Eppendorf pO(2) Histograph, Germany).Materials and methods: Thirteen patients with tumours suspected to be STS were examined by [F-18]FMISO PET scanning, and eleven of these patients completed a set of Eppendorf PO2 Histograph measurements following the scanning.Results and discussion: By histopathological diagnosis, seven tumours were shown to be STS and six tumours were benign. Ratios between tumour and muscle radioactivity and time activity curves for tumours and muscle tissue were examined in defined regions of interest. Only two malignant tumours showed [F-18]FMISO uptake in higher amounts than muscle tissue over time. Hypoxia was present in both benign and malignant tumours as measured by the oxygen electrode method.Conclusions: [F-18]FMISO PET in our setting seemed not to be feasible for the detection of tumour hypoxia in human soft tissue tumours. Neither,'id it reflect the extent of hypoxia as determined with the oxygen electrode measurements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.