Inflammatory bowel disease in Iran: A review of 457 cases
Inflammatory bowel disease in Iran: A review of 457 cases
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DOI：
10.1111/j.1440-1746.2005.03905.x
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发表时间：
2005-11-01
影响因子：
4.1
通讯作者：
Firouzi, F
中科院分区：
文献类型：
--
作者：
Aghazadeh, R;Zali, MR;Firouzi, F
背景与目的：方法：回顾性分析401例溃疡性结肠炎（UC）、47例克罗恩病（CD）和9例未定型结肠炎（IC）患者的临床资料、肠外表现、病程及并发症。结果：UC和CD患者诊断时的平均年龄分别为31.9岁和30.5岁。UC和CD的男女比例分别为0.8和1.3。不吸烟的CD和UC患者的百分比分别为82.9%和84.5%。UC患者出现直肠出血（41.9%），而CD患者主诉腹痛（46.9%）。在UC患者中，直肠乙状结肠受累率为51.9%。2例患者诊断为结直肠癌。UC和CD患者从症状发作到确诊的平均滞后时间分别为13.9和17.7个月。共32.4%的IBD患者至少有一个五个主要的肠道外diseases.Conclusion：IBD的人口和临床图片是或多或少相同的其他发展中国家，但是，罕见的CD在伊朗注意到。虽然伊朗IBD的真实流行病学特征仍然未知，但它并不像以前认为的那样罕见，似乎逐渐采用西方生活方式可能与IBD的持续上升有关（C）2005 Blackwell Publishing Asia Pty Ltd.
Background and Aims: Inflammatory bowel disease (IBD) was believed to be infrequent in Iran; however, unofficial reports have confessed the continuing rise in IBD in our country.Methods: Demographic and clinical features, extraintestinal manifestations, extension of disease and complications of 401 patients with ulcerative colitis (UC), 47 with Crohn's disease (CD), and nine with indeterminatn colitis (IC) were assessed retrospectively. The exact course of physicians' visits of 250 IBD patient was asked through face-to-face interview.Results: Mean age at diagnosis was 31.9 years in UC and 30.5 years in CD patients. The male to female ratio was 0.8 for UC and 1.3 for CD. The percentage of CD and UC patients who were non-smokers was 82.9 and 84.5%, respectively. Patients with UC presented with rectal bleeding (41.9%), whereas those with CD complained of abdominal pain (46.9%). Among UC patients, proctosigmoid was affected in 51.9%. Colorectal cancer was diagnosed in two patients. The mean lag time between the onset of symptoms and definite diagnosis was 13.9 and 17.7 months for UC and CD patients, respectively. A total of 32.4% of patients with IBD had at least one of the five major extra-intestinal diseases.Conclusion: The demographic and clinical picture of IBD is more or less the same as that of other developing countries; however, the rarity of CD in Iran is noted. Although the true epidemiologic profile of IBD in Iran is still unknown, it is not as rare as previously thought, and it seems as if gradual adoption of a Western lifestyle may be associated with the continuing rise in IBD (C) 2005 Blackwell Publishing Asia Pty Ltd.