PERIPHERAL SUPPRESSION OF 1ST PAIN AND CENTRAL SUMMATION OF 2ND PAIN EVOKED BY NOXIOUS HEAT PULSES
PERIPHERAL SUPPRESSION OF 1ST PAIN AND CENTRAL SUMMATION OF 2ND PAIN EVOKED BY NOXIOUS HEAT PULSES
复制标题
由有害热脉冲诱发的第 1 次疼痛的外周抑制和第 2 次疼痛的中枢传导
DOI：
10.1016/0304-3959(77)90035-5
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发表时间：
1977-01-01
期刊：
影响因子：
7.4
通讯作者：
GRACELY, RH
中科院分区：
文献类型：
--
作者：
PRICE, DD;HU, JW;GRACELY, RH
对6名人类受试者进行了心理物理学实验，以确定第一和第二疼痛如何受到外周受体机制和CNS抑制和易化机制的影响。传递到手的短暂的、自然的、疼痛的刺激是由接触热电极（峰值温度= 51.5 ℃）产生的一系列4-8个恒定波形的热脉冲。C）。使用跨模态匹配程序估计第一和第二疼痛感觉的幅度，并确定反应时间。后者证实了第一和第二疼痛和冲动传导之间的关系，在A. δ。和C有害热传入。当脉冲间隔为80秒或更小时，第一次疼痛的强度随着每个连续的热脉冲而降低，这种降低很可能是热诱导的A δ抑制的结果。热伤害感受器，因为如果探针位置在连续的热脉冲之间改变，则不会发生热伤害感受器。相反，如果间隔为3 s或更短，则第二次疼痛的强度随着每个连续的热脉冲而增加。这种总和最有可能是由于CNS总和机制，因为它也发生在尺神经压迫阻断第一次疼痛之后，并且当热电极的位置在热脉冲之间改变时。这些观察结果和它们的解释通过记录单个A δ的响应得到支持。热伤害性传入，C多模态伤害性传入和恒河猴的温暖传入类似的列车的有害热脉冲。他们对这些热脉冲的反应显示出渐进的抑制。背角神经元对C纤维的重复齐射（> 1/3s）表现出较宽动态范围的累加反应。这些脊髓总和机制可以解释第二次疼痛的总和。
Psychophysical experiments were carried out on 6 human subjects to determine how 1st and 2nd pain were influenced by peripheral receptor mechanisms and by CNS inhibitory and facilitatory mechanisms. The brief, natural, painful stimuli delivered to the hand were a train of 4-8 constant waveform heat pulses generated by a contact thermode (peak temperature = 51.5.degree. C). The magnitude of 1st and 2nd pain sensations was estimated using cross-modality matching procedures and reaction times were determined. The latter confirmed the relationship between 1st and 2nd pain and impulse conduction in A.delta. and C noxious heat afferents, respectively. The intensity of 1st pain decreased with each successive heat pulse when the interpulse interval was 80 s or less. This decrease was most likely the result of heat induced suppression of A.delta. heat nociceptors since it did not occur if the probe location changed between successive heat pulses. In contrast, 2nd pain increased in intensity with each successive heat pulse if the interval was 3 s or less. This summation was most likely due to CNS summation mechanisms since it also occurred after blockage of 1st pain by ulnar nerve compression and when the location of the thermode changed between heat pulses. These observations and their interpretations were supported by recording of responses of single A.delta. heat nociceptive afferents, C polymodal nociceptive afferents and warm afferents of rhesus monkeys to similar trains of noxious heat pulses. Their responses to these heat pulses showed a progressive suppression. Wide dynamic range dorsal horn neurons showed summated responses to repeated volleys in C fibers (> 1/3 s). These spinal cord summation mechanisms could account for the summation of 2nd pain.