Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists.
Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists.
复制标题
同种异体骨髓移植中的 Epstein-Barr 病毒感染：移植医生和病毒学家的教训。
DOI：
10.1007/bf01715373
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发表时间：
1992
影响因子：
3.5
通讯作者：
Ernberg,I
中科院分区：
文献类型：
--
作者：
Gratama,JW;Oosterveer,MA;Lepoutre,J;Fibbe,WE;Ringdén,O;Vossen,JM;Willemze,R;Bolhuis,RL;vanRood,JJ;Ernberg,I
EB病毒（EBV）和宿主之间的关系被异基因骨髓移植（BMT）严重扰乱，因为EBV存在于受体的造血系统中，其在大多数情况下必须被破坏，并且存在于供体的造血系统中，即，骨髓移植我们已经证明，EB病毒可以从一些骨髓移植受者中根除，并且病毒可以随着骨髓移植物转移。在移植后即刻期间，可能发生口咽部EBV排泄，其通过感染经过的B淋巴细胞，可作为急性移植物抗宿主病的辅因子并帮助病毒存活，尽管其储存库暂时耗尽。BMT受者中存在完全不同的EBV株，而健康的未输血对照者中则没有，这表明在免疫缺陷的情况下可能存在重复感染;或者，通过储存库本身（B淋巴细胞）转移病毒可能是重复感染的唯一有效途径。病毒复制过程中产生的“变异”毒株可能是人群中野生型EBV分离株之间巨大多态性的基础。
The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We have shown that EBV may be eradicated from some BMT recipients and that the virus may be transferred with the marrow graft. During the immediate post-transplant period oropharyngeal EBV excretion may occur which, by infecting passing B lymphocytes, may act as co-factor for acute graft-versus-host disease and help the virus to survive, despite the temporary depletion of its reservoir. The coexistence of totally different EBV strains in BMT recipients but not in healthy, untransfused controls, suggests that superinfection may by possible in case of immunodeficiency; alternatively, transfer of the virus by the reservoir itself (the B lymphocytes) might be the only effective route for superinfection. The generation of ‘variant’ strains during viral replication may form the basis of the vast polymorphism between wild-type EBV isolates in the population.