Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development
Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development
复制标题
东京青少年队列（pn-TTC）的人口神经科学研究：队列纵向研究，探索青少年心理和行为发展的神经生物学基础
DOI：
10.1111/pcn.12814
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发表时间：
2019
影响因子：
11.9
通讯作者：
Yamasa
中科院分区：
文献类型：
--
作者：
Okada N;Ando;Sanada;Hirata-Mogi;Iijima;Sugiyama;Shirakawa;Yamagishi;Kanehara;Morita;Yagi;Hayashi;Koshiyama;Morita;Sawada;Ikegame;Sugimoto;Toriyama;Masaoka;Fujikawa;Kanata;Tada;Kirihara;Yahata;Araki;Jinde;Kano;Koike;Endo;Yamasa
AimAdolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. Our understanding of how the maturation of endocrine, epigenetics, and brain circuit may underlie psychological development in adolescence, however, has not been integrated. Here, we introduce our research project, the population‐neuroscience study of the Tokyo TEEN Cohort (pn‐TTC), a longitudinal study to explore the neurobiological substrates of development during adolescence.MethodsParticipants in the first wave of the pn‐TTC (pn‐TTC‐1) study were recruited from those of the TTC study, a large‐scale epidemiological survey in which 3171 parent–adolescent pairs were recruited from the general population. Participants underwent psychological, cognitive, sociological, and physical assessment. Moreover, adolescents and their parents underwent magnetic resonance imaging (MRI; structural MRI, resting‐state functional MRI, and magnetic resonance spectroscopy), and adolescents provided saliva samples for hormone analysis and for DNA analysis including epigenetics. Furthermore, the second wave (pn‐TTC‐2) followed similar methods as in the first wave.ResultsA total of 301 parent–adolescent pairs participated in the pn‐TTC‐1 study. Moreover, 281 adolescents participated in the pn‐TTC‐2 study, 238 of whom were recruited from the pn‐TTC‐1 sample. The instruction for data request is available at: http://value.umin.jp/data‐resource.html.ConclusionThe pn‐TTC project is a large‐scale and population‐neuroscience‐based survey with a plan of longitudinal biennial follow up. Through this approach we seek to elucidate adolescent developmental mechanisms according to biopsychosocial models. This current biomarker research project, using minimally biased samples recruited from the general population, has the potential to expand the new research field of population neuroscience.
