The role of spectrin in erythrocyte membrane-stimulated actin polymerisation
The role of spectrin in erythrocyte membrane-stimulated actin polymerisation
复制标题
血影蛋白在红细胞膜刺激肌动蛋白聚合中的作用
作者：
C. M. Cohen;D. Branton
红细胞膜表面的蛋白质，包括血影蛋白和肌动蛋白，被认为构成了红细胞膜的细胞骨架1-3，但对肌动蛋白的作用及其与红细胞膜的关系知之甚少。我们已经报道，单体(G)肌动蛋白加入到红细胞膜表面，选择性地与细胞膜表面的一个组分结合。我们现在表明，这个组分不太可能是幽灵蛋白，肌动蛋白结合是通过刺激肌动蛋白聚合发生的。
PROTEINS on the cytoplasmic surface of the erythrocyte membrane, including spectrin and actin, are postulated to comprise the red cell cytoskeleton1–3, but little is known about the role of actin or its association with the membrane. We have reported that monomeric (G) actin added to erythrocyte ghosts selectively associates with a component at the cytoplasmic surface of the membrane4,5. We now show that this component is unlikely to be spectrin and that actin binding occurs by stimulated actin polymerisation.