CLINICOPATHOLOGIC SIGNIFICANCE OF GRANULOVACUOLAR DEGENERATION IN ALZHEIMER'S DISEASE
CLINICOPATHOLOGIC SIGNIFICANCE OF GRANULOVACUOLAR DEGENERATION IN ALZHEIMER'S DISEASE
复制标题
阿尔茨海默病中颗粒空泡变性的临床病理学意义
DOI：
10.1097/00005072-196201000-00007
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发表时间：
1962
影响因子：
3.2
通讯作者：
J. Woodard
中科院分区：
文献类型：
--
作者：
J. Woodard
在世纪之交，人们对老年性痴呆病例的海马锥体神经元中的颗粒空泡进行了观察，但这种异常的特异性程度和形态学分类的诊断价值尚未明确。本文对 200 例未经选择的各种精神疾病患者尸检中的异常情况进行了分析。海马神经元中的颗粒空泡变性是阿尔茨海默病中经常发现的现象，这使得使用常规染色方法可以轻松识别和定量。通过近似定量，异常特征具有足够的特异性，具有诊断价值，并且与更常用的形态学标准相反，颗粒空泡变性在整个“老年”年龄阶段保留了其对阿尔茨海默病临床表现的特异性。
The observation of granulovacuoles in the hippocampal pyramidal neurons in cases of senile dementia was made at the turn of the century, but the extent to which the abnormality is specific and of diagnostic value in morphologic classification has not been clearly established. An analysis of the abnormality in a series of 200 unselected autopsies on patients with all forms of mental disease is presented. Granulovacuolar degeneration among the hippocampal neurons is a constant finding in Alzheimer's disease which lends itself to easy recognition and quantitation using routine staining methods. With approximate quantitation the abnormal feature has sufficient specificity to be of diagnostic value, and, in contrast to more commonly used morphologic criteria, granulovacuolar degeneration retains its specificity for the clinical manifestations of Alzheimer's disease throughout the “senile” age period.