Risperidone treatment for juvenile bipolar disorder: A retrospective chart review
Risperidone treatment for juvenile bipolar disorder: A retrospective chart review
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DOI：
10.1097/00004583-199908000-00011
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发表时间：
1999-08-01
影响因子：
13.3
通讯作者：
Shapiro, S
中科院分区：
文献类型：
--
作者：
Frazier, JA;Meyer, MC;Shapiro, S
目的：探讨非典型抗精神病药利培酮治疗青少年躁狂症的疗效和耐受性。方法：回顾性分析某大学中心诊断为双相情感障碍（DSM-IV）的门诊患者接受利培酮治疗的病例。使用临床总体印象量表（CGI）评估治疗反应，并对躁狂、精神病、攻击和注意力缺陷/多动障碍（ADHD）进行单独评估。结果：28名双相情感障碍青年（平均+/- SD年龄，10.4 +/- 3.8岁）（25名混合型，3名轻躁型）接受利培酮治疗。这些儿童接受的平均剂量为1.7 +/- 1.3 mg，平均时间为6.1 +/- 8.5个月。使用小于或等于2分（非常/非常改善）的CGI改善评分来定义强劲的改善，82%的人在躁狂和攻击性症状上都有改善，69%的人在精神病症状上有改善，但只有8%的人在多动症症状上有改善。结论：尽管受其回顾性研究的限制，本研究提示利培酮可能有效治疗躁狂症青少年，并提示利培酮和其他非典型抗精神病药在青少年躁狂症中的对照临床试验的必要性。
Objective: To investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania. Method: This is a retrospective chart review of outpatients with the diagnosis of bipolar disorder (DSM-IV) treated with risperidone at a university center. Response to treatment was evaluated using the Clinical Global Impression Scale (CGI) with separate assessments of mania, psychosis, aggression, and attention-deficit/hyperactivity disorder (ADHD). Results: Twenty-eight youths (mean +/- SD age, 10.4 +/- 3.8 years) with bipolar disorder (25 mixed and 3 hypomanic) who had been treated with risperidone were identified. These children received a mean dose of 1.7 +/- 1.3 mg over an average period of 6.1 +/- 8.5 months. Using a CGI Improvement score of less than or equal to 2 (very much/much improved) to define robust improvement, 82% showed improvement in both their manic and aggressive symptoms, 69% in psychotic symptoms, but only 8% in ADHD symptoms. Conclusions: Although limited by its retrospective nature, this study suggests that risperidone may be effective in the treatment of manic young people and indicates the need for controlled clinical trials of risperidone and other atypical neuroleptics in juvenile mania.