Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population
Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population
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DOI：
10.1016/j.canlet.2005.10.005
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发表时间：
2006-09-08
期刊：
影响因子：
9.7
通讯作者：
Ogawa, Osamu
中科院分区：
文献类型：
--
作者：
Awakura, Yasuo;Ito, Noriyuki;Ogawa, Osamu
基质金属蛋白酶-9 （Matrix metalloproteinase-9, MMP-9）在肿瘤侵袭转移过程中起着关键作用。最近的实验研究表明，MMP-9也与早期癌变有关。我们假设MMP-9多态性影响肾癌（RCC）的易感性。为了验证这一假设，我们检测了日本RCC病例（179例）和对照组（211例）的MMP-9 C - 1562T和R279Q基因型。此外，我们还研究了MMP-9多态性与临床病理特征之间的关系。C - 1562T和R279Q基因型的分布与RCC的风险无显著相关（- 1562 CT/TT基因型与CC基因型的比值比[OR] = 1.14, 95%可信区间[CI] = 0.73-1.77； 279 RQ/QQ基因型与RR基因型的比值比[OR] = 1.29, 95% C1 = 0.86-1.93）。而R279Q基因型的分布与组织学分级呈极显著相关（P < 0.01）。提示MMP9 R279Q多态性对RCC的恶性潜能有影响。2006爱思唯尔爱尔兰有限公司版权所有。
Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in cancer invasion and metastasis. Recently, experimental study has shown that MMP-9 is also implicated in early carcinogenesis. We hypothesized that MMP-9 polymorphisms influence the predisposition to develop renal cell carcinoma (RCC). To test the hypothesis, we determined MMP-9 C - 1562T and R279Q genotypes in Japanese RCC cases (n = 179) and controls (n = 211). Furthermore, we investigated the relationship between MMP-9 polymorphisms and clinicopathological features. The distribution of C - 1562T and R279Q genotypes was not significantly associated with the risk of RCC (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 0.73-1.77 for - 1562 CT/TT genotypes versus CC genotype; OR = 1.29, 95% C1 = 0.86-1.93 for 279 RQ/QQ genotypes versus RR genotype). However, the distribution of R279Q genotypes was significantly associated with the histological grade (P < 0.01). The present results suggest that MMP9 R279Q polymorphism has influence on the malignant potential of RCC. (c) 2006 Elsevier Ireland Ltd. All rights reserved.