Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study
Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study
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DOI：
10.1111/j.1399-3038.2011.01176.x
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发表时间：
2011-11-01
影响因子：
4.4
通讯作者：
Hirota, Yoshio
中科院分区：
文献类型：
--
作者：
Miyake, Yoshihiro;Okubo, Hitomi;Hirota, Yoshio
背景资料：母亲孕期饮食可能影响儿童期变态反应性疾病的发生。目的：本前瞻性研究探讨母亲孕期饮食与16-24月龄子代喘息和湿疹风险之间的关系。母亲在怀孕期间摄入的数据进行了评估与饮食史问卷。饮食模式来自33个预定义的食物组的因素分析。喘鸣和湿疹的症状是基于儿童哮喘和过敏症国际研究的标准。调整了母亲的年龄，怀孕，居住的城市，家庭收入，母亲和父亲的教育，母亲和父亲的过敏性疾病的历史，母亲在怀孕期间的饮食变化，季节在基线，母亲在怀孕期间吸烟，婴儿的哥哥姐姐，性别，出生体重，年龄在第三次调查，家庭吸烟，母乳喂养duration.Results：三种饮食模式被确定：“健康”，特点是大量摄入绿色和黄色蔬菜、海藻、蘑菇、白色蔬菜、豆类、土豆、鱼、海产品、水果和贝类;“西方”，特点是大量摄入植物油、含盐调味品、牛肉和猪肉、加工肉类、鸡蛋、鸡肉和白色蔬菜;而“日本人”的特点是多吃米饭、味噌汤、海产品和鱼。通过粗略分析，母亲怀孕期间的西方模式与儿童喘息的风险之间存在逆暴露-反应关系的趋势。调整研究中的混杂因素后，反向关系得到加强：极端四分位数之间的调整OR为0.59（95% CI：0.35-0.98，趋势p = 0.02）。儿童湿疹没有观察到这种负相关。结论：母亲孕期西方模式对子代喘息有一定的预防作用。
Background: Maternal diet during pregnancy might influence the development of childhood allergic disorders.Aims: This prospective study examined the relationship between maternal dietary patterns during pregnancy and the risk of wheeze and eczema in the offspring aged 16-24 months.Materials & Methods: Subjects were 763 mother-child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Dietary patterns were derived from factor analysis of 33 predefined food groups. Symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood. Adjustment was made for maternal age, gestation, residential municipality, family income, maternal and paternal education, maternal and paternal history of allergic disorders, changes in maternal diet in pregnancy, season at baseline, maternal smoking during pregnancy, baby's older siblings, sex, birth weight, age at the third survey, household smoking, and breastfeeding duration.Results: Three dietary patterns were identified: 'healthy', characterized by high intake of green and yellow vegetables, seaweed, mushrooms, white vegetables, pulses, potatoes, fish, sea products, fruit, and shellfish; 'Western', characterized by high intake of vegetable oil, salt-containing seasonings, beef and pork, processed meat, eggs, chicken, and white vegetables; and 'Japanese', characterized by high intake of rice, miso soup, sea products, and fish. There was a tendency for an inverse exposure-response relationship between the maternal Western pattern during pregnancy and the risk of childhood wheeze by crude analysis. After adjustment for the confounding factors under study, the inverse relationship was strengthened: the adjusted OR between extreme quartiles was 0.59 (95% CI: 0.35-0.98, p for trend = 0.02). No such inverse association was observed for childhood eczema. Neither the maternal healthy pattern nor the Japanese pattern during pregnancy was related to childhood wheeze or eczema.Conclusion: The maternal Western pattern during pregnancy may be preventive against wheeze in the offspring.